Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000281418> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2000281418 endingPage "1189" @default.
- W2000281418 startingPage "1185" @default.
- W2000281418 abstract "We studied 24 male patients aged 26-62 years (median 41) prospectively presenting over a 5 year period with clinical features of hypogonadism and erectile dysfunction (ED), who had been treated with autologous or allogeneic bone marrow/stem cell transplant for a variety of haematological malignancies and had received either high-dose chemotherapy or high-dose chemotherapy combined with total body irradiation (TBI). Ten healthy adult controls (aged 35-50 years) were also studied. Erectile dysfunction (ED) was assessed clinically and by colour flow Doppler studies of the cavernosal vessels. Testicular function was assessed by testicular volume including orchidometry, FSH, LH and testosterone measurements. Libido and ejaculatory function were also recorded. Patients had severe hypogonadism as evidenced by low mean testicular volume (7.0 +/- 2.4 ml vs 20 +/- 2.0 ml; P < 0.001), elevated gonadotrophins (FSH = 18.54 +/- 7.61 vs 5 IU/l (P < 0.001); LH = 8.02 +/- 2.89 vs 3. 9 IU/l (P < 0.001)) and low normal mean testosterone levels (16.4 nmol/l +/- 9.1 vs 22.4 nmol/l (P < 0.5)). Cavernosal arterial insufficiency was found in 11/14 of TBI-treated and in 3/10 HDC-treated patients, indicative of vasculogenic damage to corpora cavernosal vessels. Patients were given a therapeutic trial with testosterone replacement therapy (TRT). Those who had diminished libido had a marked improvement in their symptoms but the effect of TRT on ED was equivocal. In conclusion, this is the first report to show vasculogenic insufficiency in patients with haematological malignancies treated by BMT. Although hypogonadism can account for diminished libido, arteriogenic insufficiency is likely to be an important factor accounting for ED in these patients, especially those treated by TBI. We recommend a comprehensive assessment including endocrine profile and colour flow Doppler study in formulating the best management plan in recipients of high-dose therapy presenting after transplant with ED." @default.
- W2000281418 created "2016-06-24" @default.
- W2000281418 creator A5010758275 @default.
- W2000281418 creator A5018108120 @default.
- W2000281418 creator A5020559146 @default.
- W2000281418 creator A5023394038 @default.
- W2000281418 creator A5035245655 @default.
- W2000281418 creator A5041242319 @default.
- W2000281418 creator A5061507542 @default.
- W2000281418 creator A5061967509 @default.
- W2000281418 date "2000-06-01" @default.
- W2000281418 modified "2023-10-06" @default.
- W2000281418 title "Cavernosal arterial insufficiency is a major component of erectile dysfunction in some recipients of high-dose chemotherapy/chemo-radiotherapy for haematological malignancies" @default.
- W2000281418 cites W1998885478 @default.
- W2000281418 cites W2011901078 @default.
- W2000281418 cites W2036978149 @default.
- W2000281418 cites W2040468822 @default.
- W2000281418 cites W2070016147 @default.
- W2000281418 cites W2070270400 @default.
- W2000281418 cites W2081739694 @default.
- W2000281418 cites W2082169654 @default.
- W2000281418 cites W2116849258 @default.
- W2000281418 cites W2315338268 @default.
- W2000281418 cites W2339721589 @default.
- W2000281418 cites W2419992816 @default.
- W2000281418 doi "https://doi.org/10.1038/sj.bmt.1702391" @default.
- W2000281418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10849531" @default.
- W2000281418 hasPublicationYear "2000" @default.
- W2000281418 type Work @default.
- W2000281418 sameAs 2000281418 @default.
- W2000281418 citedByCount "40" @default.
- W2000281418 countsByYear W20002814182012 @default.
- W2000281418 countsByYear W20002814182013 @default.
- W2000281418 countsByYear W20002814182014 @default.
- W2000281418 countsByYear W20002814182015 @default.
- W2000281418 countsByYear W20002814182016 @default.
- W2000281418 countsByYear W20002814182017 @default.
- W2000281418 countsByYear W20002814182018 @default.
- W2000281418 countsByYear W20002814182019 @default.
- W2000281418 countsByYear W20002814182020 @default.
- W2000281418 countsByYear W20002814182022 @default.
- W2000281418 countsByYear W20002814182023 @default.
- W2000281418 crossrefType "journal-article" @default.
- W2000281418 hasAuthorship W2000281418A5010758275 @default.
- W2000281418 hasAuthorship W2000281418A5018108120 @default.
- W2000281418 hasAuthorship W2000281418A5020559146 @default.
- W2000281418 hasAuthorship W2000281418A5023394038 @default.
- W2000281418 hasAuthorship W2000281418A5035245655 @default.
- W2000281418 hasAuthorship W2000281418A5041242319 @default.
- W2000281418 hasAuthorship W2000281418A5061507542 @default.
- W2000281418 hasAuthorship W2000281418A5061967509 @default.
- W2000281418 hasBestOaLocation W20002814181 @default.
- W2000281418 hasConcept C126322002 @default.
- W2000281418 hasConcept C126894567 @default.
- W2000281418 hasConcept C134018914 @default.
- W2000281418 hasConcept C2776694085 @default.
- W2000281418 hasConcept C2779279991 @default.
- W2000281418 hasConcept C2779366285 @default.
- W2000281418 hasConcept C2779929075 @default.
- W2000281418 hasConcept C509974204 @default.
- W2000281418 hasConcept C71924100 @default.
- W2000281418 hasConceptScore W2000281418C126322002 @default.
- W2000281418 hasConceptScore W2000281418C126894567 @default.
- W2000281418 hasConceptScore W2000281418C134018914 @default.
- W2000281418 hasConceptScore W2000281418C2776694085 @default.
- W2000281418 hasConceptScore W2000281418C2779279991 @default.
- W2000281418 hasConceptScore W2000281418C2779366285 @default.
- W2000281418 hasConceptScore W2000281418C2779929075 @default.
- W2000281418 hasConceptScore W2000281418C509974204 @default.
- W2000281418 hasConceptScore W2000281418C71924100 @default.
- W2000281418 hasIssue "11" @default.
- W2000281418 hasLocation W20002814181 @default.
- W2000281418 hasLocation W20002814182 @default.
- W2000281418 hasOpenAccess W2000281418 @default.
- W2000281418 hasPrimaryLocation W20002814181 @default.
- W2000281418 hasRelatedWork W1998113603 @default.
- W2000281418 hasRelatedWork W1999611386 @default.
- W2000281418 hasRelatedWork W1999831221 @default.
- W2000281418 hasRelatedWork W2027237635 @default.
- W2000281418 hasRelatedWork W2036308844 @default.
- W2000281418 hasRelatedWork W2047880909 @default.
- W2000281418 hasRelatedWork W2081677525 @default.
- W2000281418 hasRelatedWork W2087168955 @default.
- W2000281418 hasRelatedWork W2089877176 @default.
- W2000281418 hasRelatedWork W2100202028 @default.
- W2000281418 hasVolume "25" @default.
- W2000281418 isParatext "false" @default.
- W2000281418 isRetracted "false" @default.
- W2000281418 magId "2000281418" @default.
- W2000281418 workType "article" @default.