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- W2000282687 abstract "To The Editors: During the past decade progress has made in the prophylaxis of respiratory syncytial virus (RSV) infection by development of either polyclonal or monoclonal antibody to RSV, preventing severe lung disease in high risk infants and children. Because RSV causes annual outbreaks of disease that typically peak between January and February in countries in the northern hemisphere,1 guidelines have been established for selection of patients and duration of prophylaxis.2 Despite increasing numbers of epidemiologic data from developing countries, only few recent data are evident from Europe.3–6 In a population-based retrospective review from 1994 to 1998, 952 infants were hospitalized because of viral upper and lower respiratory tract infections at the Pediatric Department of the University Hospital Graz, a tertiary care center in Southern Austria. RSV antigen detection by immunofluorescence microscopy from nasopharyngeal aspirates was positive in 245 patients (26.7%). Eight had diagnosis of rhinopharyngitis, 44 bronchitis, 20 bronchopneumonia and 173 bronchiolitis. Of the lower respiratory tract infections 64% of cases with bronchiolitis, 5% of bronchopneumonia and 12% of bronchitis were RSV-positive. There were 203 infants (83%) ≤6 months of age, one-half of them (100) ≤2 months and only 9 children (4%) were older than 18 months of age. Predisposing conditions were congenital heart disease in 15 infants (6%) (one with cyanotic congenital heart disease), underlying pulmonary disease in 4 (2%) (none with cystic fibrosis), neurologic disease in 4 (2%) and prematurity in 23 infants (9%). Gestational ages of the 23 preterm infants were 36 (2), 35 (4), 33 (1), 32 (5), 31 (4), 30 (1), 29 (1), 28 (2) and 26 (3) weeks. One preterm infant had bronchopulmonary dysplasia. In preterm infants bronchiolitis was diagnosed in 20 (87%) cases, bronchitis in 2 (9%) cases and bronchopneumonia in 1 (4%) case. Respiratory support was needed by 18 infants (7%), 3 by nasal continuous positive airway pressure, and 15 (including 3 preterm born) infants required mechanical ventilation. None of the infants died as a result of RSV infection. The seasonal distribution of RSV infections is shown in Figure 1. Mean duration of hospitalization in 236 infants (≤30 days) was 11 days. The incidence of RSV infection requiring hospitalization in that part of Austria was 6/1000/season among term and 12/1000/season among preterm infants (P < 0.05). These data provide information about RSV disease of a small part of Austria, but they may add further information to the global perspective of RSV disease. Prospective studies currently are under way.Fig. 1: Seasonal distribution of RSV infections in 245 infants from 1994 to 1998.Bernhard Resch M.D. W. Gusenleitner M.D. C. Mandl M.D. W. Müller M.D. Division of Neonatology Pediatric Department University Hospital Graz Graz, Austria Accepted for publication March 8, 2000." @default.
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- W2000282687 date "2000-06-01" @default.
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- W2000282687 title "EPIDEMIOLOGY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN SOUTHERN AUSTRIA" @default.
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- W2000282687 doi "https://doi.org/10.1097/00006454-200006000-00030" @default.
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