FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000284524> ?p ?o ?g. }

• W2000284524 endingPage "2891" @default.
• W2000284524 startingPage "2885" @default.
• W2000284524 abstract "Many vertebrates regulate their body temperature in response to thermal variability of the environment. Endotherms maintain relatively stable body temperatures by adjusting metabolic heat production in response to varying environmental heat loads. Although most ectotherms do not display adaptive thermogenesis, they do acclimate cellular metabolism to compensate for environmental temperature variation. The components of the thermoregulatory systems in endotherms and ectotherms are evolutionarily conserved, and I suggest that metabolic acclimation in ectotherms relies on the same regulatory pathways as adaptive thermogenesis in endotherms. Both groups rely on transient receptor potential ion channels to sense environmental temperatures. Thermosensory (afferent) information is relayed to the hypothalamus, which initiates a sympathetic efferent response. Cardiovascular responses to heat are similar in ectothermic crocodiles and in mammals, and are mediated by the autonomic nervous system in both cases. The sympathetic nervous system also modulates cellular metabolism by inducing expression of the transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC-1alpha), which interacts with a range of transcription factors that control glycolysis, fatty acid oxidation, gluconeogenesis, mitochondrial biogenesis and bioenergetics, and metabolic rate. PGC-1alpha is best known from mammalian model species but there is increasing evidence that it is also instrumental in non-mammalian vertebrates. Hence, endothermic adaptive thermogenesis may result from the same regulatory pathways as ectothermic metabolic acclimation, and both could be considered as adaptive metabolic responses to temperature variation." @default.
• W2000284524 created "2016-06-24" @default.
• W2000284524 creator A5010740372 @default.
• W2000284524 date "2009-09-15" @default.
• W2000284524 modified "2023-10-08" @default.
• W2000284524 title "Responses to temperature variation: integration of thermoregulation and metabolism in vertebrates" @default.
• W2000284524 cites W1562645017 @default.
• W2000284524 cites W1575263278 @default.
• W2000284524 cites W1665938856 @default.
• W2000284524 cites W1856308032 @default.
• W2000284524 cites W1933050657 @default.
• W2000284524 cites W1964876127 @default.
• W2000284524 cites W1965509871 @default.
• W2000284524 cites W1965744141 @default.
• W2000284524 cites W1967450028 @default.
• W2000284524 cites W1975332997 @default.
• W2000284524 cites W1981805689 @default.
• W2000284524 cites W1995546044 @default.
• W2000284524 cites W1996801078 @default.
• W2000284524 cites W1997189695 @default.
• W2000284524 cites W1997541372 @default.
• W2000284524 cites W2008632158 @default.
• W2000284524 cites W2011706236 @default.
• W2000284524 cites W2014951773 @default.
• W2000284524 cites W2015962090 @default.
• W2000284524 cites W2018989853 @default.
• W2000284524 cites W2022270425 @default.
• W2000284524 cites W2022295359 @default.
• W2000284524 cites W2024957709 @default.
• W2000284524 cites W2028548249 @default.
• W2000284524 cites W2030488259 @default.
• W2000284524 cites W2039393505 @default.
• W2000284524 cites W2044477864 @default.
• W2000284524 cites W2045812316 @default.
• W2000284524 cites W2047398157 @default.
• W2000284524 cites W2047778853 @default.
• W2000284524 cites W2064651077 @default.
• W2000284524 cites W2078894227 @default.
• W2000284524 cites W2080320163 @default.
• W2000284524 cites W2089843950 @default.
• W2000284524 cites W2090714924 @default.
• W2000284524 cites W2091673304 @default.
• W2000284524 cites W2105303099 @default.
• W2000284524 cites W2105946617 @default.
• W2000284524 cites W2113197207 @default.
• W2000284524 cites W2114052187 @default.
• W2000284524 cites W2123016403 @default.
• W2000284524 cites W2123107859 @default.
• W2000284524 cites W2127902039 @default.
• W2000284524 cites W2133577354 @default.
• W2000284524 cites W2140161618 @default.
• W2000284524 cites W2140751228 @default.
• W2000284524 cites W2143622753 @default.
• W2000284524 cites W2145944506 @default.
• W2000284524 cites W2148210575 @default.
• W2000284524 cites W2155276853 @default.
• W2000284524 cites W2155412324 @default.
• W2000284524 cites W2156066001 @default.
• W2000284524 cites W2156733405 @default.
• W2000284524 cites W2160769801 @default.
• W2000284524 cites W2171272055 @default.
• W2000284524 cites W4238915379 @default.
• W2000284524 doi "https://doi.org/10.1242/jeb.024430" @default.
• W2000284524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19717669" @default.
• W2000284524 hasPublicationYear "2009" @default.
• W2000284524 type Work @default.
• W2000284524 sameAs 2000284524 @default.
• W2000284524 citedByCount "78" @default.
• W2000284524 countsByYear W20002845242012 @default.
• W2000284524 countsByYear W20002845242013 @default.
• W2000284524 countsByYear W20002845242014 @default.
• W2000284524 countsByYear W20002845242015 @default.
• W2000284524 countsByYear W20002845242016 @default.
• W2000284524 countsByYear W20002845242017 @default.
• W2000284524 countsByYear W20002845242018 @default.
• W2000284524 countsByYear W20002845242019 @default.
• W2000284524 countsByYear W20002845242020 @default.
• W2000284524 countsByYear W20002845242021 @default.
• W2000284524 countsByYear W20002845242022 @default.
• W2000284524 countsByYear W20002845242023 @default.
• W2000284524 crossrefType "journal-article" @default.
• W2000284524 hasAuthorship W2000284524A5010740372 @default.
• W2000284524 hasBestOaLocation W20002845241 @default.
• W2000284524 hasConcept C100564792 @default.
• W2000284524 hasConcept C13376991 @default.
• W2000284524 hasConcept C134018914 @default.
• W2000284524 hasConcept C151279926 @default.
• W2000284524 hasConcept C171089720 @default.
• W2000284524 hasConcept C18903297 @default.
• W2000284524 hasConcept C86803240 @default.
• W2000284524 hasConceptScore W2000284524C100564792 @default.
• W2000284524 hasConceptScore W2000284524C13376991 @default.
• W2000284524 hasConceptScore W2000284524C134018914 @default.
• W2000284524 hasConceptScore W2000284524C151279926 @default.
• W2000284524 hasConceptScore W2000284524C171089720 @default.
• W2000284524 hasConceptScore W2000284524C18903297 @default.
• W2000284524 hasConceptScore W2000284524C86803240 @default.
• W2000284524 hasIssue "18" @default.

• next