Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000284725> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000284725 endingPage "537" @default.
- W2000284725 startingPage "523" @default.
- W2000284725 abstract "Retroviruses are a family of widespread small animal viruses about 110 nm in diameter, composed of an inner core surrounded by an outer envelope formed of a lipid bilayer of cellular origin in which are anchored viral glycoproteins. The inner core is formed by an outer shell of capsid protein molecules (CA protein) surrounding the dimeric RNA genome in close association with about 2000 molecules of nucleocapsid protein (NC protein) and molecules of reverse transcriptase (RT) and integrase (IN). Conversion of the genomic single-stranded RNA into a double-stranded proviral DNA by RT takes place in the nucleocapsid substructure and involves two DNA strand transfers to generate the long terminal repeats (LTR) required for IN-mediated integration of the proviral DNA into the cellular genome and its expression. In this review we have summarized some of the properties and functions of the nucleocapsid protein of the most intensely studied oncoretroviruses (MuLV and ASLV) and lentiviruses (HIV-1). Recent biochemical and genetic data on retroviral NC proteins have shown that this small viral protein endowed with a strong affinity for nucleic acids exhibits nucleic acid annealing and strand transfer activities and is required for the formation of infectious viral particles. These new activities of NC protein are most probably necessary at the early steps of proviral DNA synthesis. The 3-D structures of HIV-1 and MoMuLV NC proteins, deduced from NMR studies, are characterized by a central globular domain with one (MoMuLV) or two (HIV-1) zinc fingers. This should facilitate a rational approach of new anti-HIV therapies based on inhibition of NC protein functions. Due to space limitations and the very abundant literature on retroviruses, references to articles prior to the publication of the second volume of RNA Tumor Viruses in 1985 (Weiss et al., 1985) will be minimal. We also direct the reader to an excellent review which summarizes recent insights into biochemical and structural aspects of the retroviral enzymes PR, RT and IN (Katz & Skalka, 1994)." @default.
- W2000284725 created "2016-06-24" @default.
- W2000284725 creator A5032132304 @default.
- W2000284725 creator A5054249539 @default.
- W2000284725 creator A5073903197 @default.
- W2000284725 creator A5084052195 @default.
- W2000284725 date "1995-12-01" @default.
- W2000284725 modified "2023-10-13" @default.
- W2000284725 title "First Glimpses at Structure-function Relationships of the Nucleocapsid Protein of Retroviruses" @default.
- W2000284725 doi "https://doi.org/10.1006/jmbi.1995.0635" @default.
- W2000284725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7500330" @default.
- W2000284725 hasPublicationYear "1995" @default.
- W2000284725 type Work @default.
- W2000284725 sameAs 2000284725 @default.
- W2000284725 citedByCount "390" @default.
- W2000284725 countsByYear W20002847252012 @default.
- W2000284725 countsByYear W20002847252013 @default.
- W2000284725 countsByYear W20002847252014 @default.
- W2000284725 countsByYear W20002847252015 @default.
- W2000284725 countsByYear W20002847252016 @default.
- W2000284725 countsByYear W20002847252017 @default.
- W2000284725 countsByYear W20002847252018 @default.
- W2000284725 countsByYear W20002847252019 @default.
- W2000284725 countsByYear W20002847252020 @default.
- W2000284725 countsByYear W20002847252021 @default.
- W2000284725 countsByYear W20002847252022 @default.
- W2000284725 crossrefType "journal-article" @default.
- W2000284725 hasAuthorship W2000284725A5032132304 @default.
- W2000284725 hasAuthorship W2000284725A5054249539 @default.
- W2000284725 hasAuthorship W2000284725A5073903197 @default.
- W2000284725 hasAuthorship W2000284725A5084052195 @default.
- W2000284725 hasConcept C104317684 @default.
- W2000284725 hasConcept C108625454 @default.
- W2000284725 hasConcept C141231307 @default.
- W2000284725 hasConcept C14430832 @default.
- W2000284725 hasConcept C153911025 @default.
- W2000284725 hasConcept C156719811 @default.
- W2000284725 hasConcept C159047783 @default.
- W2000284725 hasConcept C185592680 @default.
- W2000284725 hasConcept C202878990 @default.
- W2000284725 hasConcept C24107716 @default.
- W2000284725 hasConcept C24284526 @default.
- W2000284725 hasConcept C2522874641 @default.
- W2000284725 hasConcept C54355233 @default.
- W2000284725 hasConcept C552990157 @default.
- W2000284725 hasConcept C67705224 @default.
- W2000284725 hasConcept C6881719 @default.
- W2000284725 hasConcept C86339819 @default.
- W2000284725 hasConcept C86803240 @default.
- W2000284725 hasConcept C97380033 @default.
- W2000284725 hasConceptScore W2000284725C104317684 @default.
- W2000284725 hasConceptScore W2000284725C108625454 @default.
- W2000284725 hasConceptScore W2000284725C141231307 @default.
- W2000284725 hasConceptScore W2000284725C14430832 @default.
- W2000284725 hasConceptScore W2000284725C153911025 @default.
- W2000284725 hasConceptScore W2000284725C156719811 @default.
- W2000284725 hasConceptScore W2000284725C159047783 @default.
- W2000284725 hasConceptScore W2000284725C185592680 @default.
- W2000284725 hasConceptScore W2000284725C202878990 @default.
- W2000284725 hasConceptScore W2000284725C24107716 @default.
- W2000284725 hasConceptScore W2000284725C24284526 @default.
- W2000284725 hasConceptScore W2000284725C2522874641 @default.
- W2000284725 hasConceptScore W2000284725C54355233 @default.
- W2000284725 hasConceptScore W2000284725C552990157 @default.
- W2000284725 hasConceptScore W2000284725C67705224 @default.
- W2000284725 hasConceptScore W2000284725C6881719 @default.
- W2000284725 hasConceptScore W2000284725C86339819 @default.
- W2000284725 hasConceptScore W2000284725C86803240 @default.
- W2000284725 hasConceptScore W2000284725C97380033 @default.
- W2000284725 hasIssue "4" @default.
- W2000284725 hasLocation W20002847251 @default.
- W2000284725 hasLocation W20002847252 @default.
- W2000284725 hasOpenAccess W2000284725 @default.
- W2000284725 hasPrimaryLocation W20002847251 @default.
- W2000284725 hasRelatedWork W1517043843 @default.
- W2000284725 hasRelatedWork W1582992312 @default.
- W2000284725 hasRelatedWork W1848337419 @default.
- W2000284725 hasRelatedWork W1972585314 @default.
- W2000284725 hasRelatedWork W2014255145 @default.
- W2000284725 hasRelatedWork W2027181586 @default.
- W2000284725 hasRelatedWork W2046697522 @default.
- W2000284725 hasRelatedWork W2094692623 @default.
- W2000284725 hasRelatedWork W2404761508 @default.
- W2000284725 hasRelatedWork W66799780 @default.
- W2000284725 hasVolume "254" @default.
- W2000284725 isParatext "false" @default.
- W2000284725 isRetracted "false" @default.
- W2000284725 magId "2000284725" @default.
- W2000284725 workType "article" @default.