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- W2000286674 abstract "The introduction of calcineurin inhibitors (CNI) revolutionized kidney transplantation (KTx). Exceptionally low acute rejection rates and excellent graft survival could be achieved with CNI-based (cyclosporine and tacrolimus) immunosuppressive protocols. However, despite short-term success, long-term graft attrition continues to be a significant problem, thus leaving clinicians looking for possible interventions. CNI nephrotoxicity is but one of numerous factors that may be contributing to long-term damage in transplant kidneys. Therefore, newer immunosuppressive agents such as mycophenolate mofetil and sirolimus (Rapa) have raised the possibility of withdrawing or avoiding CNIs altogether. Protocols exploring these options have gained greater attention over the last few years. Herein, we review studies addressing either CNI withdrawal or CNI avoidance strategies as well as discuss the risks versus benefits of these protocols. Given the accumulated experience to date, in our opinion, the use of CNIs as a part of immunosuppressive regimens remains the proven standard of care for renal transplant patients. The long-term safety and efficacy of CNI withdrawal and avoidance strategies need to be further validated in controlled clinical trials." @default.
- W2000286674 created "2016-06-24" @default.
- W2000286674 creator A5070667307 @default.
- W2000286674 creator A5071725578 @default.
- W2000286674 creator A5087164252 @default.
- W2000286674 date "2007-10-01" @default.
- W2000286674 modified "2023-09-25" @default.
- W2000286674 title "Calcineurin inhibitor-free immunosuppression in kidney transplantation" @default.
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- W2000286674 doi "https://doi.org/10.1111/j.1432-2277.2007.00528.x" @default.
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