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- W2000287112 abstract "The sensitivity of the human keratinocyte cell line HaCaT to several lichen metabolites isolated from Parmelia nepalensis and Parmelia tinctorum was evaluated. The tridepside gyrophoric acid (6), the dibenzofuran derivative (+)-usnic acid (1), and the didepside diffractaic acid (5) were potent antiproliferative agents and inhibited cell growth, with IC50 values of 1.7, 2.1, and 2.6 μM, respectively. Methyl β-orcinolcarboxylate (2), ethyl hematommate (3), the didepside atranorin (4), and (+)-protolichesterinic acid (7) did not influence keratinocyte growth at concentrations of 5 μM. Keratinocytes were further tested for their susceptibility to the action of the potent antiproliferative agents on plasma membrane integrity. The release of lactate dehydrogenase activity into the culture medium was unchanged as compared to controls, documenting that the activity of gyrophoric acid (6), (+)-usnic acid (1), and diffractaic acid (5) was due to cytostatic rather than cytotoxic effects." @default.
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- W2000287112 date "1999-05-06" @default.
- W2000287112 modified "2023-09-25" @default.
- W2000287112 title "Lichen Metabolites. 2. Antiproliferative and Cytotoxic Activity of Gyrophoric, Usnic, and Diffractaic Acid on Human Keratinocyte Growth" @default.
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- W2000287112 doi "https://doi.org/10.1021/np980378z" @default.
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