Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000287530> ?p ?o ?g. }
- W2000287530 endingPage "277" @default.
- W2000287530 startingPage "268" @default.
- W2000287530 abstract "Proteome analysis was performed on cellular and secreted proteins of normal (quiescent) and activated rat hepatic stellate cells. The stellate cells were activated either in vitro by cultivating quiescent stellate cells for 9 days or in vivo by injecting rats with carbon tetrachloride for 8 weeks. A total of 43 proteins/polypeptides were identified, which altered their expression levels when the cells were activated in vivo and/or in vitro. Twenty-seven of them showed similar changes in vivo and in vitro, including up-regulated proteins such as calcyclin, calgizzarin, and galectin-1 as well as down-regulated proteins such as liver carboxylesterase 10 and serine protease inhibitor 3. Sixteen of them showed different expression levels between in vivo and in vitro activated stellate cells. These results were reproducibly obtained in 3 independent experiments. The up-regulation of calcyclin, calgizzarin, and galectin-1, as well as the down-regulation of liver carboxylesterase 10 were directly confirmed in fibrotic liver tissues. Northern blots confirmed up-regulation of the messenger RNAs (mRNAs) of calcyclin, calgizzarin, and galectin-1 in activated stellate cells, indicating that these changes were controlled at the mRNA level. In addition a list compiling over 150 stellate cell proteins is presented. The data presented here thus provide a significant new protein-level insight into the activation of hepatic stellate cells, a key event in liver fibrogenesis." @default.
- W2000287530 created "2016-06-24" @default.
- W2000287530 creator A5006704013 @default.
- W2000287530 creator A5008377317 @default.
- W2000287530 creator A5015020453 @default.
- W2000287530 creator A5024647870 @default.
- W2000287530 creator A5043244059 @default.
- W2000287530 creator A5085790083 @default.
- W2000287530 creator A5087434980 @default.
- W2000287530 creator A5090266837 @default.
- W2000287530 date "2000-08-01" @default.
- W2000287530 modified "2023-10-14" @default.
- W2000287530 title "Proteome analysis of rat hepatic stellate cells" @default.
- W2000287530 cites W1238224877 @default.
- W2000287530 cites W1489754394 @default.
- W2000287530 cites W1528295287 @default.
- W2000287530 cites W1537193766 @default.
- W2000287530 cites W1537279861 @default.
- W2000287530 cites W1603116547 @default.
- W2000287530 cites W1606423922 @default.
- W2000287530 cites W1613102183 @default.
- W2000287530 cites W179452321 @default.
- W2000287530 cites W1985550503 @default.
- W2000287530 cites W1991694882 @default.
- W2000287530 cites W1992210469 @default.
- W2000287530 cites W1996361792 @default.
- W2000287530 cites W2017218231 @default.
- W2000287530 cites W2018245355 @default.
- W2000287530 cites W2018571987 @default.
- W2000287530 cites W2020470909 @default.
- W2000287530 cites W2023021687 @default.
- W2000287530 cites W2027944956 @default.
- W2000287530 cites W2031717125 @default.
- W2000287530 cites W2035700643 @default.
- W2000287530 cites W2044059517 @default.
- W2000287530 cites W2048760229 @default.
- W2000287530 cites W2065460644 @default.
- W2000287530 cites W2069750547 @default.
- W2000287530 cites W2076804243 @default.
- W2000287530 cites W2079965684 @default.
- W2000287530 cites W2082645615 @default.
- W2000287530 cites W2092052153 @default.
- W2000287530 cites W2093893875 @default.
- W2000287530 cites W2094731629 @default.
- W2000287530 cites W2121418514 @default.
- W2000287530 cites W2129984889 @default.
- W2000287530 cites W2146421447 @default.
- W2000287530 cites W2161105539 @default.
- W2000287530 doi "https://doi.org/10.1053/jhep.2000.9322" @default.
- W2000287530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10915733" @default.
- W2000287530 hasPublicationYear "2000" @default.
- W2000287530 type Work @default.
- W2000287530 sameAs 2000287530 @default.
- W2000287530 citedByCount "195" @default.
- W2000287530 countsByYear W20002875302012 @default.
- W2000287530 countsByYear W20002875302013 @default.
- W2000287530 countsByYear W20002875302014 @default.
- W2000287530 countsByYear W20002875302015 @default.
- W2000287530 countsByYear W20002875302016 @default.
- W2000287530 countsByYear W20002875302017 @default.
- W2000287530 countsByYear W20002875302018 @default.
- W2000287530 countsByYear W20002875302020 @default.
- W2000287530 countsByYear W20002875302021 @default.
- W2000287530 countsByYear W20002875302022 @default.
- W2000287530 countsByYear W20002875302023 @default.
- W2000287530 crossrefType "journal-article" @default.
- W2000287530 hasAuthorship W2000287530A5006704013 @default.
- W2000287530 hasAuthorship W2000287530A5008377317 @default.
- W2000287530 hasAuthorship W2000287530A5015020453 @default.
- W2000287530 hasAuthorship W2000287530A5024647870 @default.
- W2000287530 hasAuthorship W2000287530A5043244059 @default.
- W2000287530 hasAuthorship W2000287530A5085790083 @default.
- W2000287530 hasAuthorship W2000287530A5087434980 @default.
- W2000287530 hasAuthorship W2000287530A5090266837 @default.
- W2000287530 hasBestOaLocation W20002875301 @default.
- W2000287530 hasConcept C104317684 @default.
- W2000287530 hasConcept C104397665 @default.
- W2000287530 hasConcept C105580179 @default.
- W2000287530 hasConcept C134018914 @default.
- W2000287530 hasConcept C150903083 @default.
- W2000287530 hasConcept C153911025 @default.
- W2000287530 hasConcept C176891718 @default.
- W2000287530 hasConcept C185592680 @default.
- W2000287530 hasConcept C195521686 @default.
- W2000287530 hasConcept C202751555 @default.
- W2000287530 hasConcept C207001950 @default.
- W2000287530 hasConcept C2908801736 @default.
- W2000287530 hasConcept C55493867 @default.
- W2000287530 hasConcept C86803240 @default.
- W2000287530 hasConcept C95444343 @default.
- W2000287530 hasConceptScore W2000287530C104317684 @default.
- W2000287530 hasConceptScore W2000287530C104397665 @default.
- W2000287530 hasConceptScore W2000287530C105580179 @default.
- W2000287530 hasConceptScore W2000287530C134018914 @default.
- W2000287530 hasConceptScore W2000287530C150903083 @default.
- W2000287530 hasConceptScore W2000287530C153911025 @default.
- W2000287530 hasConceptScore W2000287530C176891718 @default.
- W2000287530 hasConceptScore W2000287530C185592680 @default.