FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000288269> ?p ?o ?g. }

• W2000288269 endingPage "1009" @default.
• W2000288269 startingPage "1002" @default.
• W2000288269 abstract "Mesangial cell (MC) proliferation, a histopathologic feature common to many human glomerular diseases, is regulated by several growth factors through their binding to specific cell surface receptors. Platelet-derived growth factor (PDGF) is a peptide exerting a potent mitogenic activity on MC. Recently, an increased expression of both PDGF protein and its receptor has been localized in the mesangial areas of several experimental as well as human proliferative glomerulonephritides (GN). Thus, it may be postulated that the inhibition of PDGF action could prevent MC proliferation during mesangial proliferative GN. Trapidil, an antiplatelet drug, has been shown to inhibit the growth of several cell types both in vitro and in vivo. The present study was aimed at evaluating the effect of Trapidil on human MC in vitro. The addition of 100 to 400 micrograms/ml Trapidil significantly reduced cell proliferation induced by different growth factors (FCS, PDGF-BB, bFGF, EGF), the highest inhibitory effect being on PDGF-BB stimulated MC growth. The effect of the drug was dose-dependent and seemingly specific: aspirin was devoid of any anti-proliferative action, while dypiridamole proved to be toxic. Receptor binding experiments showed that Trapidil competitively inhibited 125I-PDGF-BB binding to its cell surface receptors, without inducing receptor internalization, at least after short-term (2 hr) incubation. In contrast, long-term (48 hr) exposure to 400 micrograms/ml Trapidil caused a sharp increase of PDGF-BB binding. Similar effects on cell proliferation and 125I-PDGF-BB binding were observed when NIH-3T3 fibroblasts were exposed to the test substance.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2000288269 created "2016-06-24" @default.
• W2000288269 creator A5001391327 @default.
• W2000288269 creator A5002347643 @default.
• W2000288269 creator A5015151099 @default.
• W2000288269 creator A5050569543 @default.
• W2000288269 creator A5091868996 @default.
• W2000288269 date "1994-10-01" @default.
• W2000288269 modified "2023-09-27" @default.
• W2000288269 title "Trapidil inhibits human mesangiai cell proliferation: Effect on PDGF β-receptor binding and expression" @default.
• W2000288269 cites W1493414055 @default.
• W2000288269 cites W1547002699 @default.
• W2000288269 cites W1586111947 @default.
• W2000288269 cites W1589156173 @default.
• W2000288269 cites W1985527771 @default.
• W2000288269 cites W1991577267 @default.
• W2000288269 cites W1996052299 @default.
• W2000288269 cites W1996385798 @default.
• W2000288269 cites W2019829774 @default.
• W2000288269 cites W2030381707 @default.
• W2000288269 cites W2036901793 @default.
• W2000288269 cites W2056557043 @default.
• W2000288269 cites W2062018389 @default.
• W2000288269 cites W2062748780 @default.
• W2000288269 cites W2067805667 @default.
• W2000288269 cites W2069311345 @default.
• W2000288269 cites W2078663145 @default.
• W2000288269 cites W2080282961 @default.
• W2000288269 cites W2085295620 @default.
• W2000288269 cites W2091960256 @default.
• W2000288269 cites W2093352141 @default.
• W2000288269 cites W2104649033 @default.
• W2000288269 cites W2148371225 @default.
• W2000288269 cites W2303555161 @default.
• W2000288269 cites W2324405418 @default.
• W2000288269 cites W4294216491 @default.
• W2000288269 doi "https://doi.org/10.1038/ki.1994.360" @default.
• W2000288269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7861694" @default.
• W2000288269 hasPublicationYear "1994" @default.
• W2000288269 type Work @default.
• W2000288269 sameAs 2000288269 @default.
• W2000288269 citedByCount "55" @default.
• W2000288269 countsByYear W20002882692012 @default.
• W2000288269 countsByYear W20002882692013 @default.
• W2000288269 countsByYear W20002882692016 @default.
• W2000288269 countsByYear W20002882692018 @default.
• W2000288269 countsByYear W20002882692019 @default.
• W2000288269 crossrefType "journal-article" @default.
• W2000288269 hasAuthorship W2000288269A5001391327 @default.
• W2000288269 hasAuthorship W2000288269A5002347643 @default.
• W2000288269 hasAuthorship W2000288269A5015151099 @default.
• W2000288269 hasAuthorship W2000288269A5050569543 @default.
• W2000288269 hasAuthorship W2000288269A5091868996 @default.
• W2000288269 hasBestOaLocation W20002882691 @default.
• W2000288269 hasConcept C126322002 @default.
• W2000288269 hasConcept C134018914 @default.
• W2000288269 hasConcept C139770010 @default.
• W2000288269 hasConcept C170493617 @default.
• W2000288269 hasConcept C180361614 @default.
• W2000288269 hasConcept C185592680 @default.
• W2000288269 hasConcept C2775960820 @default.
• W2000288269 hasConcept C2779131090 @default.
• W2000288269 hasConcept C2780091579 @default.
• W2000288269 hasConcept C2781294074 @default.
• W2000288269 hasConcept C55493867 @default.
• W2000288269 hasConcept C62112901 @default.
• W2000288269 hasConcept C71924100 @default.
• W2000288269 hasConcept C86803240 @default.
• W2000288269 hasConcept C95444343 @default.
• W2000288269 hasConceptScore W2000288269C126322002 @default.
• W2000288269 hasConceptScore W2000288269C134018914 @default.
• W2000288269 hasConceptScore W2000288269C139770010 @default.
• W2000288269 hasConceptScore W2000288269C170493617 @default.
• W2000288269 hasConceptScore W2000288269C180361614 @default.
• W2000288269 hasConceptScore W2000288269C185592680 @default.
• W2000288269 hasConceptScore W2000288269C2775960820 @default.
• W2000288269 hasConceptScore W2000288269C2779131090 @default.
• W2000288269 hasConceptScore W2000288269C2780091579 @default.
• W2000288269 hasConceptScore W2000288269C2781294074 @default.
• W2000288269 hasConceptScore W2000288269C55493867 @default.
• W2000288269 hasConceptScore W2000288269C62112901 @default.
• W2000288269 hasConceptScore W2000288269C71924100 @default.
• W2000288269 hasConceptScore W2000288269C86803240 @default.
• W2000288269 hasConceptScore W2000288269C95444343 @default.
• W2000288269 hasIssue "4" @default.
• W2000288269 hasLocation W20002882691 @default.
• W2000288269 hasLocation W20002882692 @default.
• W2000288269 hasOpenAccess W2000288269 @default.
• W2000288269 hasPrimaryLocation W20002882691 @default.
• W2000288269 hasRelatedWork W1971652814 @default.
• W2000288269 hasRelatedWork W1999701259 @default.
• W2000288269 hasRelatedWork W2024986848 @default.
• W2000288269 hasRelatedWork W2029464998 @default.
• W2000288269 hasRelatedWork W2085295620 @default.
• W2000288269 hasRelatedWork W2152699459 @default.
• W2000288269 hasRelatedWork W2368953762 @default.
• W2000288269 hasRelatedWork W2397833923 @default.
• W2000288269 hasRelatedWork W2408270317 @default.

• next