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- W2000289726 abstract "An approach for an animal MRI-compatible ventilator is described, which might be useful for some applications, such as those dependent on gas flow. The ventilator has been optimized for small rodents, although the instrument may easily be conveyed to human scale. Its essential features are a real-time module that also prevents lung overpressure, control from a personal computer through a versatile parallel port, small dead volume (0.24 ± 0.02 cm3 and about 0.8 cm3, including the endotracheal tube volume), and a specifically designed pneumatic breathing module compatible with hyperpolarized gases. One distinguishing characteristic from previously published approaches is a fast-acting open/close pneumatic valve arrangement (delays are lower than 5 ms after software postcorrection) that allows the system to reproduce animal breathing rates and to generate different breathing patterns and gas mixtures. The gas mixing compositions quantified from valve opening times agree (error lower than 3 %) with the experimental values measured by mass spectrometry. The inspiratory and expiratory transit time delays (opening and closing pneumatic ports) are short and highly reproducible. The ventilator has been evaluated in vivo for different breathing patterns with rats using MRI techniques, as it includes an additional stage to acquire NMR data or locate excitation pulses in synchronism with a specific point in the respiratory cycle. Finally, it has been made using locally available low-cost materials, and no system faults or errors have been reported during 1 year of operation. © 2005 Wiley Periodicals, Inc. Concepts Magn Reson 26B: 93–103, 2005." @default.
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- W2000289726 date "2005-01-01" @default.
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- W2000289726 title "A fully MRI-compatible animal ventilator for special-gas mixing applications" @default.
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- W2000289726 doi "https://doi.org/10.1002/cmr.b.20036" @default.
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