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- W2000291456 abstract "Background/Aim To study circulating gastrin profile, both fasting and postprandially, in patients with achlorhydria due to auto-immune atrophic gastritis, comparing these with normal healthy controls. Methods Circulating gastrins were measured using three region-specific radio-immunoassays: amidated gastrins (R98), N-terminal G34 (R526) and N-terminal G17 (GP168). Samples were analysed further using gel chromatography. Results Fasting gastrin concentrations were elevated in achlorhydria as measured using all three antisera: median 714 pmol/l (range 107–5176) in achlorhydria versus 12 pmol/l (2–33) in controls (R98), 343 pmol/l (45–4316) versus 10 pmol/l (5–41) (R526), and 720 pmol/l (14–6000) versus 2 pmol/l (1–10) (GP168). In patients, 47° of gastrin was amidated (95° in controls) and 30° was processed N-terminally only to G71 (4° in controls). Gastrin rose significantly postprandially: 1643 pmol/l (269–7142) in patients versus 24 pmol/l (5–142) in controls (R98), 432 pmol/l (113–4756) versus 15 pmol/l (7–45) (R526) and 2189 pmol/l (304–7150) versus 15 pmol/l (7–45) (GP168). Only 25° was amidated in the patient group (93.5% in controls) and 21% remained as component I (4% in controls). Conclusions This abnormal gastrin profile associated with hypergastrinaemia secondary to achlorhydria is consistent with saturation of the enzymes involved in the processing of the pro-hormone, in particular amidation of the C- terminus." @default.
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- W2000291456 date "1999-06-01" @default.
- W2000291456 modified "2023-10-16" @default.
- W2000291456 title "Molecular forms of gastrin in the circulation of patients with achlorhydria" @default.
- W2000291456 doi "https://doi.org/10.1097/00042737-199906000-00013" @default.
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