Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000291768> ?p ?o ?g. }
- W2000291768 endingPage "1608" @default.
- W2000291768 startingPage "1596" @default.
- W2000291768 abstract "DXZ4 is an X-linked macrosatellite composed of 12-100 tandemly arranged 3-kb repeat units. In females, it adopts opposite chromatin arrangements at the two alleles in response to X-chromosome inactivation. In males and on the active X chromosome, it is packaged into heterochromatin, but on the inactive X chromosome (Xi), it adopts a euchromatic conformation bound by CTCF. Here we report that the ubiquitous transcription factor YY1 associates with the euchromatic form of DXZ4 on the Xi. The binding of YY1 close to CTCF is reminiscent of that at other epigenetically regulated sequences, including sites of genomic imprinting, and at the X-inactivation centre, suggesting a common mode of action in this arrangement. As with CTCF, binding of YY1 to DXZ4 in vitro is not blocked by CpG methylation, yet in vivo both proteins are restricted to the hypomethylated form. In several male carcinoma cell lines, DXZ4 can adopt a Xi-like conformation in response to cellular transformation, characterized by CpG hypomethylation and binding of YY1 and CTCF. Analysis of a male melanoma cell line and normal skin cells from the same individual confirmed that a transition in chromatin state occurred in response to transformation." @default.
- W2000291768 created "2016-06-24" @default.
- W2000291768 creator A5013708533 @default.
- W2000291768 creator A5014352567 @default.
- W2000291768 creator A5017818437 @default.
- W2000291768 creator A5040267135 @default.
- W2000291768 creator A5057240643 @default.
- W2000291768 creator A5088403077 @default.
- W2000291768 date "2011-11-07" @default.
- W2000291768 modified "2023-10-10" @default.
- W2000291768 title "YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas" @default.
- W2000291768 cites W1523020113 @default.
- W2000291768 cites W1544691147 @default.
- W2000291768 cites W1643500256 @default.
- W2000291768 cites W1669374546 @default.
- W2000291768 cites W1831033366 @default.
- W2000291768 cites W1964930281 @default.
- W2000291768 cites W1966805460 @default.
- W2000291768 cites W1969467454 @default.
- W2000291768 cites W1973743253 @default.
- W2000291768 cites W1974650443 @default.
- W2000291768 cites W1977175163 @default.
- W2000291768 cites W1978330010 @default.
- W2000291768 cites W1979513687 @default.
- W2000291768 cites W1979826516 @default.
- W2000291768 cites W1984218466 @default.
- W2000291768 cites W1986137167 @default.
- W2000291768 cites W1991811149 @default.
- W2000291768 cites W1992574814 @default.
- W2000291768 cites W1995514235 @default.
- W2000291768 cites W1997252697 @default.
- W2000291768 cites W1997581867 @default.
- W2000291768 cites W1997901919 @default.
- W2000291768 cites W2001320007 @default.
- W2000291768 cites W2001841820 @default.
- W2000291768 cites W2015272213 @default.
- W2000291768 cites W2017840637 @default.
- W2000291768 cites W2018222564 @default.
- W2000291768 cites W2020958409 @default.
- W2000291768 cites W2024736438 @default.
- W2000291768 cites W2026556066 @default.
- W2000291768 cites W2029146706 @default.
- W2000291768 cites W2032247293 @default.
- W2000291768 cites W2042447441 @default.
- W2000291768 cites W204316109 @default.
- W2000291768 cites W2043317822 @default.
- W2000291768 cites W2043395729 @default.
- W2000291768 cites W2054750734 @default.
- W2000291768 cites W2058151080 @default.
- W2000291768 cites W2068978501 @default.
- W2000291768 cites W2074906225 @default.
- W2000291768 cites W2075291231 @default.
- W2000291768 cites W2075704285 @default.
- W2000291768 cites W2079165897 @default.
- W2000291768 cites W2080519471 @default.
- W2000291768 cites W2081324839 @default.
- W2000291768 cites W2082127114 @default.
- W2000291768 cites W2088433039 @default.
- W2000291768 cites W2096878022 @default.
- W2000291768 cites W2101378716 @default.
- W2000291768 cites W2106582601 @default.
- W2000291768 cites W2107051809 @default.
- W2000291768 cites W2110912061 @default.
- W2000291768 cites W2112001233 @default.
- W2000291768 cites W2115795607 @default.
- W2000291768 cites W2118562875 @default.
- W2000291768 cites W2125585142 @default.
- W2000291768 cites W2129391801 @default.
- W2000291768 cites W2155095982 @default.
- W2000291768 cites W2157873533 @default.
- W2000291768 cites W2158923719 @default.
- W2000291768 cites W2168909179 @default.
- W2000291768 cites W2396497343 @default.
- W2000291768 cites W2612812586 @default.
- W2000291768 cites W3023082015 @default.
- W2000291768 doi "https://doi.org/10.1093/nar/gkr964" @default.
- W2000291768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3287207" @default.
- W2000291768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22064860" @default.
- W2000291768 hasPublicationYear "2011" @default.
- W2000291768 type Work @default.
- W2000291768 sameAs 2000291768 @default.
- W2000291768 citedByCount "18" @default.
- W2000291768 countsByYear W20002917682012 @default.
- W2000291768 countsByYear W20002917682014 @default.
- W2000291768 countsByYear W20002917682015 @default.
- W2000291768 countsByYear W20002917682016 @default.
- W2000291768 countsByYear W20002917682018 @default.
- W2000291768 countsByYear W20002917682020 @default.
- W2000291768 countsByYear W20002917682022 @default.
- W2000291768 crossrefType "journal-article" @default.
- W2000291768 hasAuthorship W2000291768A5013708533 @default.
- W2000291768 hasAuthorship W2000291768A5014352567 @default.
- W2000291768 hasAuthorship W2000291768A5017818437 @default.
- W2000291768 hasAuthorship W2000291768A5040267135 @default.
- W2000291768 hasAuthorship W2000291768A5057240643 @default.
- W2000291768 hasAuthorship W2000291768A5088403077 @default.
- W2000291768 hasBestOaLocation W20002917681 @default.
- W2000291768 hasConcept C100924687 @default.