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- W2000292004 abstract "Abstract A number of beta receptor antagonists, which have been shown in intact animals to selectively block certain beta receptors, were compared according to their ability to modify the isoproterenol induced inhibitory response in isolated guinea pig tracheal spiral strips. On the basis of pA2 values the order of beta receptor blocking activity for the agents studied was propranolol > pronethalol > practolol > butoxamine = MJ 1999. Differences in regression line coefficients, which in addition to the pA2 values were obtained from the plot of log (x−1) against the log concentration of the antagonist (−pA×), and the degree of parallel shifting of the isoproterenol concentration-response curves suggest fundamental differences in the beta receptor blocking mechanisms for propranolol and pronethalol versus practolol, MJ 1999 and butoxamine. Dihydroergotamine was not a competitive beta receptor antagonist in the guinea-pig trachea." @default.
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- W2000292004 title "The actions of selective β-receptor antagonists on the guinea pig trachea" @default.
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- W2000292004 doi "https://doi.org/10.1016/0014-2999(70)90255-4" @default.
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