FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000292298> ?p ?o ?g. }

• W2000292298 endingPage "90" @default.
• W2000292298 startingPage "83" @default.
• W2000292298 abstract "Our previous study demonstrated that permanent two-vessel occlusion (2VO)-induced working memory deficit was improved by daily administration of tacrine, a cholinesterase inhibitor. In this study, we investigated the mechanism underlying the effects of tacrine in 2VO rats using the eight-arm radial maze task. Daily administration of tacrine (0.1 or 0.3 mg/kg i.p.) started 5 weeks after the 2VO operation significantly improved the maze performance. In the delay-interposition task, a significant impairment of maze performance was observed in the tacrine (0.3 mg/kg, i.p.)-treated rats at a delay of 90 min but not delays of 5 or 30 min. Sham-operated rats were not affected by delay. After leaving animals with no further treatment for 4 weeks, the tacrine-pretreated 2VO rats showed significantly impaired performance compared to the sham-operated control animals. However, the performance of the tacrine-pretreated 2VO rats was significantly improved by restarting the daily administration of tacrine (0.3 mg/kg, i.p.). The effect of tacrine was reversed by the muscarinic antagonist scopolamine and the selective M1 antagonist pirenzepine. Moreover, a microdialysis study revealed that tacrine (1 or 3 mg/kg, i.p.) increased the extracellular acetylcholine (ACh) level for a period of over 3 h in the cerebral cortex of 2VO rats. These findings suggest that the ameliorative effect of tacrine on the spatial memory deficit in 2VO rats is reversible and may be mediated by stimulating the muscarinic M1 receptor via elevation of the extracellular ACh level in the brain." @default.
• W2000292298 created "2016-06-24" @default.
• W2000292298 creator A5030144808 @default.
• W2000292298 creator A5036883729 @default.
• W2000292298 creator A5055360718 @default.
• W2000292298 creator A5057672918 @default.
• W2000292298 creator A5077000550 @default.
• W2000292298 date "2000-04-01" @default.
• W2000292298 modified "2023-09-23" @default.
• W2000292298 title "Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation" @default.
• W2000292298 cites W1966092733 @default.
• W2000292298 cites W1971883260 @default.
• W2000292298 cites W1978845608 @default.
• W2000292298 cites W1989190174 @default.
• W2000292298 cites W1989846049 @default.
• W2000292298 cites W1997373012 @default.
• W2000292298 cites W2012503544 @default.
• W2000292298 cites W2018417348 @default.
• W2000292298 cites W2037986097 @default.
• W2000292298 cites W2039420052 @default.
• W2000292298 cites W2047875536 @default.
• W2000292298 cites W2050637794 @default.
• W2000292298 cites W2052625961 @default.
• W2000292298 cites W2065476101 @default.
• W2000292298 cites W2071869098 @default.
• W2000292298 cites W2076719196 @default.
• W2000292298 cites W2076962338 @default.
• W2000292298 cites W2088856242 @default.
• W2000292298 cites W2089505805 @default.
• W2000292298 cites W2090016962 @default.
• W2000292298 cites W2125283476 @default.
• W2000292298 cites W2142901667 @default.
• W2000292298 cites W2147818820 @default.
• W2000292298 cites W2163815564 @default.
• W2000292298 cites W2314133009 @default.
• W2000292298 cites W2316669081 @default.
• W2000292298 cites W33005929 @default.
• W2000292298 doi "https://doi.org/10.1016/s0166-4328(99)00162-x" @default.
• W2000292298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10699660" @default.
• W2000292298 hasPublicationYear "2000" @default.
• W2000292298 type Work @default.
• W2000292298 sameAs 2000292298 @default.
• W2000292298 citedByCount "24" @default.
• W2000292298 countsByYear W20002922982012 @default.
• W2000292298 countsByYear W20002922982014 @default.
• W2000292298 countsByYear W20002922982016 @default.
• W2000292298 countsByYear W20002922982018 @default.
• W2000292298 countsByYear W20002922982020 @default.
• W2000292298 crossrefType "journal-article" @default.
• W2000292298 hasAuthorship W2000292298A5030144808 @default.
• W2000292298 hasAuthorship W2000292298A5036883729 @default.
• W2000292298 hasAuthorship W2000292298A5055360718 @default.
• W2000292298 hasAuthorship W2000292298A5057672918 @default.
• W2000292298 hasAuthorship W2000292298A5077000550 @default.
• W2000292298 hasConcept C126322002 @default.
• W2000292298 hasConcept C134018914 @default.
• W2000292298 hasConcept C15744967 @default.
• W2000292298 hasConcept C170493617 @default.
• W2000292298 hasConcept C181199279 @default.
• W2000292298 hasConcept C185592680 @default.
• W2000292298 hasConcept C22885893 @default.
• W2000292298 hasConcept C24998067 @default.
• W2000292298 hasConcept C2775910092 @default.
• W2000292298 hasConcept C2776723954 @default.
• W2000292298 hasConcept C2776885963 @default.
• W2000292298 hasConcept C2777544248 @default.
• W2000292298 hasConcept C2778816929 @default.
• W2000292298 hasConcept C2779046751 @default.
• W2000292298 hasConcept C31896038 @default.
• W2000292298 hasConcept C33789571 @default.
• W2000292298 hasConcept C55493867 @default.
• W2000292298 hasConcept C71924100 @default.
• W2000292298 hasConcept C98274493 @default.
• W2000292298 hasConceptScore W2000292298C126322002 @default.
• W2000292298 hasConceptScore W2000292298C134018914 @default.
• W2000292298 hasConceptScore W2000292298C15744967 @default.
• W2000292298 hasConceptScore W2000292298C170493617 @default.
• W2000292298 hasConceptScore W2000292298C181199279 @default.
• W2000292298 hasConceptScore W2000292298C185592680 @default.
• W2000292298 hasConceptScore W2000292298C22885893 @default.
• W2000292298 hasConceptScore W2000292298C24998067 @default.
• W2000292298 hasConceptScore W2000292298C2775910092 @default.
• W2000292298 hasConceptScore W2000292298C2776723954 @default.
• W2000292298 hasConceptScore W2000292298C2776885963 @default.
• W2000292298 hasConceptScore W2000292298C2777544248 @default.
• W2000292298 hasConceptScore W2000292298C2778816929 @default.
• W2000292298 hasConceptScore W2000292298C2779046751 @default.
• W2000292298 hasConceptScore W2000292298C31896038 @default.
• W2000292298 hasConceptScore W2000292298C33789571 @default.
• W2000292298 hasConceptScore W2000292298C55493867 @default.
• W2000292298 hasConceptScore W2000292298C71924100 @default.
• W2000292298 hasConceptScore W2000292298C98274493 @default.
• W2000292298 hasIssue "1" @default.
• W2000292298 hasLocation W20002922981 @default.
• W2000292298 hasLocation W20002922982 @default.
• W2000292298 hasOpenAccess W2000292298 @default.
• W2000292298 hasPrimaryLocation W20002922981 @default.
• W2000292298 hasRelatedWork W1966333896 @default.

• next