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• W2000292536 abstract "Inherited mutations in either the CDKN2A or CDK4 gene contribute to melanoma susceptibility in carriers. The CDKN2A gene encodes two important cell-cycle regulatory proteins, p16 and p14ARF. The Melanoma Genetics Consortium (which consists of most of the research groups worldwide that have published research on germline mutations in melanoma families) has previously published a consensus statement on genetic testing for melanoma. This statement recommended that such testing should only be carried out in the context of clinical research. 1 Kefford RF Newton Bishop JA Bergman W Tucker MA Counseling and DNA testing for individuals perceived to be genetically predisposed to melanoma: a consensus statement of the Melanoma Genetics Consortium. J Clin Oncol. 1999; 17: 3245-3251 Crossref PubMed Scopus (182) Google Scholar Recently, however, because of the vigorous promotion of a commercially available DNA test for CDKN2A mutations, and the availability of new data on the incidence of melanoma in mutation carriers (penetrance”), 2 Bishop DT Demenais F Goldstein GM et al. Geographical variation in the penetrance of CDKN2A mutations for melanoma. J Natl Cancer Inst. 2002; 94: 894-903 Crossref PubMed Scopus (409) Google Scholar the Consortium has reviewed its original recommendations. In light of these new developments, the Consortium still recommends that it is premature to offer CDKN2A testing." @default.
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• W2000292536 date "2002-11-01" @default.
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• W2000292536 title "Genetic testing for melanoma" @default.
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• W2000292536 doi "https://doi.org/10.1016/s1470-2045(02)00894-x" @default.
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