FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000293458> ?p ?o ?g. }

• W2000293458 endingPage "68" @default.
• W2000293458 startingPage "59" @default.
• W2000293458 abstract "The effect of the degradation of extracellular hyaluronan on the proliferation of human skin fibroblasts in serial cultures during in vitro aging was investigated. Human skin fibroblasts at different time intervals from 3rd to 36th passages were exposed after plating to bovine testicular hyaluronidase. The enzyme treatment resulted in an increase in cell proliferation (cell number vs. time) as compared to the untreated control fibroblasts. The effect was dose dependent, reversible, and was independent of the type of the glycosidic linkage cleaved in hyaluronan. The increased proliferation was observed at all passages when untreated cells underwent mitosis. The degradation of hyaluronan induced cell proliferation up to the presenescent phase. Depletion of hyaluronan did not induce proliferation of postmitotic fibroblasts. The incorporation of 3H-glucosamine into hyaluronan decreased with increasing cell passages (increase of the number of population doublings). Twenty-fourth passage fibroblasts accumulated about two time less hyaluronan in the medium than ninth passage cultures. Following hyaluronidase treatment, the amount of newly synthesized, labeled hyaluronan increased in the medium. Accordingly, the fibroblasts restored the degraded hyaluronan even in the declining phase of proliferation (phase III according to Hayflick)." @default.
• W2000293458 created "2016-06-24" @default.
• W2000293458 creator A5006467698 @default.
• W2000293458 creator A5025087225 @default.
• W2000293458 date "1993-01-01" @default.
• W2000293458 modified "2023-10-16" @default.
• W2000293458 title "Stimulation of cell proliferation by hyaluronidase during in vitro aging of human skin fibroblasts" @default.
• W2000293458 cites W1537090927 @default.
• W2000293458 cites W1549556389 @default.
• W2000293458 cites W1995003331 @default.
• W2000293458 cites W2004314923 @default.
• W2000293458 cites W2009171728 @default.
• W2000293458 cites W2021903763 @default.
• W2000293458 cites W2022207071 @default.
• W2000293458 cites W2047330128 @default.
• W2000293458 cites W2071698080 @default.
• W2000293458 cites W2072817825 @default.
• W2000293458 cites W2075355160 @default.
• W2000293458 cites W2121727346 @default.
• W2000293458 cites W2163117011 @default.
• W2000293458 cites W2411708802 @default.
• W2000293458 cites W32471076 @default.
• W2000293458 cites W4251144546 @default.
• W2000293458 cites W4376596386 @default.
• W2000293458 cites W91710746 @default.
• W2000293458 doi "https://doi.org/10.1016/0531-5565(93)90020-e" @default.
• W2000293458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8436205" @default.
• W2000293458 hasPublicationYear "1993" @default.
• W2000293458 type Work @default.
• W2000293458 sameAs 2000293458 @default.
• W2000293458 citedByCount "19" @default.
• W2000293458 countsByYear W20002934582012 @default.
• W2000293458 countsByYear W20002934582015 @default.
• W2000293458 countsByYear W20002934582016 @default.
• W2000293458 countsByYear W20002934582017 @default.
• W2000293458 countsByYear W20002934582019 @default.
• W2000293458 countsByYear W20002934582020 @default.
• W2000293458 countsByYear W20002934582021 @default.
• W2000293458 crossrefType "journal-article" @default.
• W2000293458 hasAuthorship W2000293458A5006467698 @default.
• W2000293458 hasAuthorship W2000293458A5025087225 @default.
• W2000293458 hasConcept C105702510 @default.
• W2000293458 hasConcept C134018914 @default.
• W2000293458 hasConcept C1491633281 @default.
• W2000293458 hasConcept C153911025 @default.
• W2000293458 hasConcept C16685009 @default.
• W2000293458 hasConcept C181199279 @default.
• W2000293458 hasConcept C189165786 @default.
• W2000293458 hasConcept C202751555 @default.
• W2000293458 hasConcept C24998067 @default.
• W2000293458 hasConcept C2777459323 @default.
• W2000293458 hasConcept C2777529286 @default.
• W2000293458 hasConcept C2780375986 @default.
• W2000293458 hasConcept C2780381497 @default.
• W2000293458 hasConcept C2908647359 @default.
• W2000293458 hasConcept C54355233 @default.
• W2000293458 hasConcept C55493867 @default.
• W2000293458 hasConcept C62112901 @default.
• W2000293458 hasConcept C66640590 @default.
• W2000293458 hasConcept C71924100 @default.
• W2000293458 hasConcept C86803240 @default.
• W2000293458 hasConcept C93304396 @default.
• W2000293458 hasConcept C95444343 @default.
• W2000293458 hasConcept C99454951 @default.
• W2000293458 hasConceptScore W2000293458C105702510 @default.
• W2000293458 hasConceptScore W2000293458C134018914 @default.
• W2000293458 hasConceptScore W2000293458C1491633281 @default.
• W2000293458 hasConceptScore W2000293458C153911025 @default.
• W2000293458 hasConceptScore W2000293458C16685009 @default.
• W2000293458 hasConceptScore W2000293458C181199279 @default.
• W2000293458 hasConceptScore W2000293458C189165786 @default.
• W2000293458 hasConceptScore W2000293458C202751555 @default.
• W2000293458 hasConceptScore W2000293458C24998067 @default.
• W2000293458 hasConceptScore W2000293458C2777459323 @default.
• W2000293458 hasConceptScore W2000293458C2777529286 @default.
• W2000293458 hasConceptScore W2000293458C2780375986 @default.
• W2000293458 hasConceptScore W2000293458C2780381497 @default.
• W2000293458 hasConceptScore W2000293458C2908647359 @default.
• W2000293458 hasConceptScore W2000293458C54355233 @default.
• W2000293458 hasConceptScore W2000293458C55493867 @default.
• W2000293458 hasConceptScore W2000293458C62112901 @default.
• W2000293458 hasConceptScore W2000293458C66640590 @default.
• W2000293458 hasConceptScore W2000293458C71924100 @default.
• W2000293458 hasConceptScore W2000293458C86803240 @default.
• W2000293458 hasConceptScore W2000293458C93304396 @default.
• W2000293458 hasConceptScore W2000293458C95444343 @default.
• W2000293458 hasConceptScore W2000293458C99454951 @default.
• W2000293458 hasIssue "1" @default.
• W2000293458 hasLocation W20002934581 @default.
• W2000293458 hasLocation W20002934582 @default.
• W2000293458 hasOpenAccess W2000293458 @default.
• W2000293458 hasPrimaryLocation W20002934581 @default.
• W2000293458 hasRelatedWork W1997495029 @default.
• W2000293458 hasRelatedWork W2019136523 @default.
• W2000293458 hasRelatedWork W2040213057 @default.
• W2000293458 hasRelatedWork W2079784375 @default.
• W2000293458 hasRelatedWork W2130227220 @default.
• W2000293458 hasRelatedWork W2164616824 @default.

• next