Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000293611> ?p ?o ?g. }
- W2000293611 endingPage "71" @default.
- W2000293611 startingPage "63" @default.
- W2000293611 abstract "The Staphylococcus epidermidis derived epidermin was the first lantibiotic that has been shown to be ribosomally synthesized and posttranslationally modified. Together with gallidermin, produced by Staphylococcus gallinarum, they belong to the large class of cationic antimicrobial peptides (CAMPs) that act against a broad spectrum of Gram-positive bacteria. Here we describe the genetic organization, biosynthesis and modification, excretion, extracellular activation of the modified pre-peptide by proteolytic processing, self-protection of the producer, gene regulation, structure, and the mode of action of gallidermin and epidermin. We also address mechanisms of bacterial tolerance to these lantibiotics and other CAMPs. Particularly gallidermin has a high potential for therapeutic application, as it is active against methicillin-resistant Staphylococcus aureus strains (MRSA) and as it is able to prevent biofilm formation at sublethal concentrations." @default.
- W2000293611 created "2016-06-24" @default.
- W2000293611 creator A5011365651 @default.
- W2000293611 creator A5014079362 @default.
- W2000293611 creator A5038731990 @default.
- W2000293611 creator A5070724072 @default.
- W2000293611 creator A5086345479 @default.
- W2000293611 date "2014-01-01" @default.
- W2000293611 modified "2023-10-03" @default.
- W2000293611 title "Epidermin and gallidermin: Staphylococcal lantibiotics" @default.
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