FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000293858> ?p ?o ?g. }

• W2000293858 endingPage "112" @default.
• W2000293858 startingPage "105" @default.
• W2000293858 abstract "The action of testosterone (T) on the sex accessory organs, such as ventral prostate (VP) and seminal vesicles (SV) is amplified by its 5α-reduction to dihydrotestosterone (DHT). This does not happen in the case of muscle (levator ani, LA) which contains little or no 5α-reductase activity. It has been suggested that the regulation of gonadotropins by T may also be mediated by its 5α-reduced metabolites. We investigated this question by utilizing two types of androgens: (1) T and 17α-methyl-testosterone (17MT), whose potency increases following 5α-reduction; and (2) 19-nortestosterone (NT) and 17α-methyl-19-nortestosterone (17MNT) whose potency decreases following 5α-reduction. Castrated rats were used to investigate the ability of these androgens to stimulate VP, and SV (androgenic action) and LA growth (anabolic action) and to suppress the post-castration rise in LH levels. In addition, modification of these actions by a 5α-reductase inhibitor (5α-RI) was studied. Compared to T, NT was approximately 5 times less potent in stimulating VP and SV. By contrast, it was twice as potent as T in stimulating LA growth. Similarly, 17MNT was 5 times less androgenic but twice as anabolic as 17MT. The antigonadotropic potency of both the 19-nor compounds was 2–3 times greater than that of their respective 19-methylated parent compounds. The similarity in their anabolic and antigonadotropic potency suggested that 5α-reduction is not a factor in their antigoanabolic and antigonadotropic potency suggested that 5α-reduction is not a factor in their antigonadotropic action. This was confirmed by the use of the 5α-RI. Treatment of rats receiving the androgens with 5α-RI showed that it decreases the androgenic activity of T and 17MT while it increases the androgenic activity of NT and 17 MNT. In all cases the anabolic activity and the antigonadotropic potency remained unchanged. It is concluded that the regulation of pituitary gonadotropin secretion by T does not depend upon its 5α-reduction to DHT." @default.
• W2000293858 created "2016-06-24" @default.
• W2000293858 creator A5000451293 @default.
• W2000293858 creator A5002762738 @default.
• W2000293858 creator A5010477243 @default.
• W2000293858 date "1995-01-01" @default.
• W2000293858 modified "2023-09-23" @default.
• W2000293858 title "Feedback regulation of gonadotropins by androgens in rats: is 5α-reduction involved?" @default.
• W2000293858 cites W1506942093 @default.
• W2000293858 cites W1965184715 @default.
• W2000293858 cites W1965369175 @default.
• W2000293858 cites W1966937657 @default.
• W2000293858 cites W1968297662 @default.
• W2000293858 cites W1971651105 @default.
• W2000293858 cites W1977618074 @default.
• W2000293858 cites W1985482837 @default.
• W2000293858 cites W1985841978 @default.
• W2000293858 cites W1987623378 @default.
• W2000293858 cites W1990869246 @default.
• W2000293858 cites W1991655420 @default.
• W2000293858 cites W1995423304 @default.
• W2000293858 cites W1998994155 @default.
• W2000293858 cites W2009205014 @default.
• W2000293858 cites W2021915979 @default.
• W2000293858 cites W2032603988 @default.
• W2000293858 cites W2037604352 @default.
• W2000293858 cites W2039670199 @default.
• W2000293858 cites W2040024990 @default.
• W2000293858 cites W2040298111 @default.
• W2000293858 cites W2040489415 @default.
• W2000293858 cites W2049960961 @default.
• W2000293858 cites W2053119838 @default.
• W2000293858 cites W2057535584 @default.
• W2000293858 cites W2059590773 @default.
• W2000293858 cites W2059863814 @default.
• W2000293858 cites W2067872836 @default.
• W2000293858 cites W2071924429 @default.
• W2000293858 cites W2084213738 @default.
• W2000293858 cites W2089668370 @default.
• W2000293858 cites W2091097631 @default.
• W2000293858 cites W2117230181 @default.
• W2000293858 cites W2132450885 @default.
• W2000293858 cites W2132591430 @default.
• W2000293858 cites W2134222723 @default.
• W2000293858 cites W4233555444 @default.
• W2000293858 cites W4239320376 @default.
• W2000293858 doi "https://doi.org/10.1016/0960-0760(94)00150-k" @default.
• W2000293858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7857869" @default.
• W2000293858 hasPublicationYear "1995" @default.
• W2000293858 type Work @default.
• W2000293858 sameAs 2000293858 @default.
• W2000293858 citedByCount "17" @default.
• W2000293858 countsByYear W20002938582015 @default.
• W2000293858 crossrefType "journal-article" @default.
• W2000293858 hasAuthorship W2000293858A5000451293 @default.
• W2000293858 hasAuthorship W2000293858A5002762738 @default.
• W2000293858 hasAuthorship W2000293858A5010477243 @default.
• W2000293858 hasConcept C1008401 @default.
• W2000293858 hasConcept C126322002 @default.
• W2000293858 hasConcept C134018914 @default.
• W2000293858 hasConcept C185592680 @default.
• W2000293858 hasConcept C202751555 @default.
• W2000293858 hasConcept C2777911890 @default.
• W2000293858 hasConcept C2779279991 @default.
• W2000293858 hasConcept C2779480814 @default.
• W2000293858 hasConcept C2779881493 @default.
• W2000293858 hasConcept C55493867 @default.
• W2000293858 hasConcept C57992300 @default.
• W2000293858 hasConcept C71315377 @default.
• W2000293858 hasConcept C71924100 @default.
• W2000293858 hasConcept C86803240 @default.
• W2000293858 hasConceptScore W2000293858C1008401 @default.
• W2000293858 hasConceptScore W2000293858C126322002 @default.
• W2000293858 hasConceptScore W2000293858C134018914 @default.
• W2000293858 hasConceptScore W2000293858C185592680 @default.
• W2000293858 hasConceptScore W2000293858C202751555 @default.
• W2000293858 hasConceptScore W2000293858C2777911890 @default.
• W2000293858 hasConceptScore W2000293858C2779279991 @default.
• W2000293858 hasConceptScore W2000293858C2779480814 @default.
• W2000293858 hasConceptScore W2000293858C2779881493 @default.
• W2000293858 hasConceptScore W2000293858C55493867 @default.
• W2000293858 hasConceptScore W2000293858C57992300 @default.
• W2000293858 hasConceptScore W2000293858C71315377 @default.
• W2000293858 hasConceptScore W2000293858C71924100 @default.
• W2000293858 hasConceptScore W2000293858C86803240 @default.
• W2000293858 hasIssue "1" @default.
• W2000293858 hasLocation W20002938581 @default.
• W2000293858 hasLocation W20002938582 @default.
• W2000293858 hasOpenAccess W2000293858 @default.
• W2000293858 hasPrimaryLocation W20002938581 @default.
• W2000293858 hasRelatedWork W1981433740 @default.
• W2000293858 hasRelatedWork W1987914672 @default.
• W2000293858 hasRelatedWork W2000293858 @default.
• W2000293858 hasRelatedWork W2016149193 @default.
• W2000293858 hasRelatedWork W2027210979 @default.
• W2000293858 hasRelatedWork W2059176014 @default.
• W2000293858 hasRelatedWork W2063133456 @default.
• W2000293858 hasRelatedWork W2071498212 @default.

• next