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- W2000293859 endingPage "e25199" @default.
- W2000293859 startingPage "e25199" @default.
- W2000293859 abstract "The dynamin-related GTPase protein OPA1, localized in the intermembrane space and tethered to the inner membrane of mitochondria, participates in the fusion of these organelles. Its mutation is the most prevalent cause of Autosomal Dominant Optic Atrophy. OPA1 controls the diameter of the junctions between the boundary part of the inner membrane and the membrane of cristae and reduces the diffusibility of cytochrome c through these junctions. We postulated that if significant Ca2+ uptake into the matrix occurs from the lumen of the cristae, reduced expression of OPA1 would increase the access of Ca2+ to the transporters in the crista membrane and thus would enhance Ca2+ uptake. In intact H295R adrenocortical and HeLa cells cytosolic Ca2+ signals evoked with K+ and histamine, respectively, were transferred into the mitochondria. The rate and amplitude of mitochondrial [Ca2+] rise (followed with confocal laser scanning microscopy and FRET measurements with fluorescent wide-field microscopy) were increased after knockdown of OPA1, as compared with cells transfected with control RNA or mitofusin1 siRNA. Ca2+ uptake was enhanced despite reduced mitochondrial membrane potential. In permeabilized cells the rate of Ca2+ uptake by depolarized mitochondria was also increased in OPA1-silenced cells. The participation of Na+/Ca2+ and Ca2+/H+ antiporters in this transport process is indicated by pharmacological data. Altogether, our observations reveal the significance of OPA1 in the control of mitochondrial Ca2+ metabolism." @default.
- W2000293859 created "2016-06-24" @default.
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- W2000293859 date "2011-09-29" @default.
- W2000293859 modified "2023-10-17" @default.
- W2000293859 title "The Effect of OPA1 on Mitochondrial Ca2+ Signaling" @default.
- W2000293859 cites W1156084614 @default.
- W2000293859 cites W150246076 @default.
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- W2000293859 cites W1967445833 @default.
- W2000293859 cites W1968135563 @default.
- W2000293859 cites W1972476228 @default.
- W2000293859 cites W1986560775 @default.
- W2000293859 cites W1986996580 @default.
- W2000293859 cites W1987220341 @default.
- W2000293859 cites W1989540421 @default.
- W2000293859 cites W1991055482 @default.
- W2000293859 cites W2001819241 @default.
- W2000293859 cites W2002791298 @default.
- W2000293859 cites W2003346050 @default.
- W2000293859 cites W2007289467 @default.
- W2000293859 cites W2008925266 @default.
- W2000293859 cites W2009278410 @default.
- W2000293859 cites W2010572143 @default.
- W2000293859 cites W2010959744 @default.
- W2000293859 cites W2011614492 @default.
- W2000293859 cites W2013091489 @default.
- W2000293859 cites W2013151879 @default.
- W2000293859 cites W2017567300 @default.
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- W2000293859 cites W2024182748 @default.
- W2000293859 cites W2030145039 @default.
- W2000293859 cites W2033673006 @default.
- W2000293859 cites W2041001616 @default.
- W2000293859 cites W2045051886 @default.
- W2000293859 cites W2046211197 @default.
- W2000293859 cites W2049262586 @default.
- W2000293859 cites W2060081012 @default.
- W2000293859 cites W2065569764 @default.
- W2000293859 cites W2068394285 @default.
- W2000293859 cites W2073095545 @default.
- W2000293859 cites W2085441242 @default.
- W2000293859 cites W2087631291 @default.
- W2000293859 cites W2091746183 @default.
- W2000293859 cites W2093921916 @default.
- W2000293859 cites W2094113524 @default.
- W2000293859 cites W2099954870 @default.
- W2000293859 cites W2102371450 @default.
- W2000293859 cites W2102626915 @default.
- W2000293859 cites W2107950396 @default.
- W2000293859 cites W2108482197 @default.
- W2000293859 cites W2115448092 @default.
- W2000293859 cites W2115944704 @default.
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- W2000293859 cites W2130758099 @default.
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- W2000293859 cites W2139625864 @default.
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- W2000293859 cites W2144194420 @default.
- W2000293859 cites W2148185042 @default.
- W2000293859 cites W2153535707 @default.
- W2000293859 cites W2154778632 @default.
- W2000293859 cites W2158329042 @default.
- W2000293859 cites W2158498299 @default.
- W2000293859 cites W2158712715 @default.
- W2000293859 cites W2161291398 @default.
- W2000293859 cites W2168310850 @default.
- W2000293859 cites W2168546428 @default.
- W2000293859 cites W2172127581 @default.
- W2000293859 cites W2336443091 @default.
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- W2000293859 doi "https://doi.org/10.1371/journal.pone.0025199" @default.
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