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• W2000293969 abstract "Abstract The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's disease are still unknown. The discovery of genes associated with Parkinson's disease (such as alpha synuclein (SNCA), E3 ubiquitin protein ligase (parkin), DJ‐1 (PARK7), ubiquitin carboxyl‐terminal hydrolase isozyme L1 (UCHL‐1), serine/threonine‐protein kinase (PINK‐1), leucine‐rich repeat kinase 2 (LRRK2), cation‐transporting ATPase 13A1 (ATP13A), etc.) contributed enormously to basic research towards understanding the role of these proteins in the sporadic form of the disease. However, it is generally accepted by the scientific community that mitochondria dysfunction, alpha synuclein aggregation, dysfunction of protein degradation, oxidative stress and neuroinflammation are involved in neurodegeneration. Dopamine oxidation seems to be a complex pathway in which dopamine o ‐quinone, aminochrome and 5,6‐indolequinone are formed. However, both dopamine o ‐quinone and 5,6‐indolequinone are so unstable that is difficult to study and separate their roles in the degenerative process occurring in Parkinson's disease. Dopamine oxidation to dopamine o ‐quinone, aminochrome and 5,6‐indolequinone seems to play an important role in the neurodegenerative processes of Parkinson's disease as aminochrome induces: (i) mitochondria dysfunction, (ii) formation and stabilization of neurotoxic protofibrils of alpha synuclein, (iii) protein degradation dysfunction of both proteasomal and lysosomal systems and (iv) oxidative stress. The neurotoxic effects of aminochrome in dopaminergic neurons can be inhibited by: (i) preventing dopamine oxidation of the transporter that takes up dopamine into monoaminergic vesicles with low pH and dopamine oxidative deamination catalyzed by monoamino oxidase (ii) dopamine o ‐quinone, aminochrome and 5,6‐indolequinone polymerization to neuromelanin and (iii) two‐electron reduction of aminochrome catalyzed by DT‐diaphorase. Furthermore, dopamine conversion to NM seems to have a dual role, protective and toxic, depending mostly on the cellular context. image Dopamine oxidation to dopamine o ‐quinone, aminochrome and 5,6‐indolequinone plays an important role in neurodegeneration in Parkinson's disease since they induce mitochondria and protein degradation dysfunction; formation of neurotoxic alpha synuclein protofibrils and oxidative stress. However, the cells have a protective system against dopamine oxidation composed by dopamine uptake mediated by Vesicular monoaminergic transporter‐2 (VMAT‐2), neuromelanin formation, two‐electron reduction and GSH‐conjugation mediated by Glutathione S ‐transferase M2‐2 (GSTM2)." @default.
• W2000293969 created "2016-06-24" @default.
• W2000293969 creator A5030347715 @default.
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• W2000293969 date "2014-03-18" @default.
• W2000293969 modified "2023-10-16" @default.
• W2000293969 title "Protective and toxic roles of dopamine in Parkinson's disease" @default.
• W2000293969 cites W1514135333 @default.
• W2000293969 cites W1521854746 @default.
• W2000293969 cites W1533585728 @default.
• W2000293969 cites W1556657736 @default.
• W2000293969 cites W1558984540 @default.
• W2000293969 cites W1574480801 @default.
• W2000293969 cites W1577439606 @default.
• W2000293969 cites W1580386428 @default.
• W2000293969 cites W1588992473 @default.
• W2000293969 cites W1600621704 @default.
• W2000293969 cites W1601438958 @default.
• W2000293969 cites W1611919433 @default.
• W2000293969 cites W1737137385 @default.
• W2000293969 cites W1856532105 @default.
• W2000293969 cites W1877873625 @default.
• W2000293969 cites W193891455 @default.
• W2000293969 cites W1963577160 @default.
• W2000293969 cites W1965024373 @default.
• W2000293969 cites W1966748491 @default.
• W2000293969 cites W1966998608 @default.
• W2000293969 cites W1967922486 @default.
• W2000293969 cites W1968497394 @default.
• W2000293969 cites W1973385523 @default.
• W2000293969 cites W1973867608 @default.
• W2000293969 cites W1974210616 @default.
• W2000293969 cites W1974924674 @default.
• W2000293969 cites W1975188689 @default.
• W2000293969 cites W1978429445 @default.
• W2000293969 cites W1979975559 @default.
• W2000293969 cites W1985613988 @default.
• W2000293969 cites W1985842394 @default.
• W2000293969 cites W1985855275 @default.
• W2000293969 cites W1986351290 @default.
• W2000293969 cites W1986696867 @default.
• W2000293969 cites W1987409772 @default.
• W2000293969 cites W1988236119 @default.
• W2000293969 cites W1991160830 @default.
• W2000293969 cites W1992925361 @default.
• W2000293969 cites W1993398728 @default.
• W2000293969 cites W1999385317 @default.
• W2000293969 cites W2000285385 @default.
• W2000293969 cites W2000956059 @default.
• W2000293969 cites W2001727865 @default.
• W2000293969 cites W2002116511 @default.
• W2000293969 cites W2004349171 @default.
• W2000293969 cites W2005496382 @default.
• W2000293969 cites W2006597186 @default.
• W2000293969 cites W2006696253 @default.
• W2000293969 cites W2007424950 @default.
• W2000293969 cites W2007750105 @default.
• W2000293969 cites W2008158988 @default.
• W2000293969 cites W2008886854 @default.
• W2000293969 cites W2009083104 @default.
• W2000293969 cites W2009952192 @default.
• W2000293969 cites W2011805483 @default.
• W2000293969 cites W2011850283 @default.
• W2000293969 cites W2012347071 @default.
• W2000293969 cites W2012609836 @default.
• W2000293969 cites W2013260853 @default.
• W2000293969 cites W2013819259 @default.
• W2000293969 cites W2014793858 @default.
• W2000293969 cites W2015528067 @default.
• W2000293969 cites W2015540133 @default.
• W2000293969 cites W2016228585 @default.
• W2000293969 cites W2016344599 @default.
• W2000293969 cites W2016775666 @default.
• W2000293969 cites W2017254759 @default.
• W2000293969 cites W2017621114 @default.
• W2000293969 cites W2017737272 @default.
• W2000293969 cites W2023709314 @default.
• W2000293969 cites W2028177630 @default.
• W2000293969 cites W2028992179 @default.
• W2000293969 cites W2032587951 @default.
• W2000293969 cites W2032870207 @default.
• W2000293969 cites W2037039276 @default.
• W2000293969 cites W2039403847 @default.
• W2000293969 cites W2042665953 @default.
• W2000293969 cites W2042695207 @default.
• W2000293969 cites W2043461502 @default.
• W2000293969 cites W2043676089 @default.
• W2000293969 cites W2044596057 @default.
• W2000293969 cites W2045753389 @default.
• W2000293969 cites W2046189898 @default.
• W2000293969 cites W2046346572 @default.
• W2000293969 cites W2046560738 @default.
• W2000293969 cites W2047541051 @default.
• W2000293969 cites W2049176126 @default.

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