Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000295352> ?p ?o ?g. }
- W2000295352 endingPage "3966" @default.
- W2000295352 startingPage "3952" @default.
- W2000295352 abstract "Macrophage inflammatory protein-1 (MIP-1), MIP-1α (CCL3) and MIP-1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1α and MIP-1β form high-molecular-weight aggregates. Our crystal structures reveal that MIP-1 aggregation is a polymerization process and human MIP-1α and MIP-1β form rod-shaped, double-helical polymers. Biophysical analyses and mathematical modelling show that MIP-1 reversibly forms a polydisperse distribution of rod-shaped polymers in solution. Polymerization buries receptor-binding sites of MIP-1α, thus depolymerization mutations enhance MIP-1α to arrest monocytes onto activated human endothelium. However, same depolymerization mutations render MIP-1α ineffective in mouse peritoneal cell recruitment. Mathematical modelling reveals that, for a long-range chemotaxis of MIP-1, polymerization could protect MIP-1 from proteases that selectively degrade monomeric MIP-1. Insulin-degrading enzyme (IDE) is identified as such a protease and decreased expression of IDE leads to elevated MIP-1 levels in microglial cells. Our structural and proteomic studies offer a molecular basis for selective degradation of MIP-1. The regulated MIP-1 polymerization and selective inactivation of MIP-1 monomers by IDE could aid in controlling the MIP-1 chemotactic gradient for immune surveillance." @default.
- W2000295352 created "2016-06-24" @default.
- W2000295352 creator A5001883769 @default.
- W2000295352 creator A5013607512 @default.
- W2000295352 creator A5033409338 @default.
- W2000295352 creator A5038808458 @default.
- W2000295352 creator A5041615081 @default.
- W2000295352 creator A5043432385 @default.
- W2000295352 creator A5049387493 @default.
- W2000295352 creator A5051454827 @default.
- W2000295352 creator A5066886337 @default.
- W2000295352 creator A5072398869 @default.
- W2000295352 creator A5075498364 @default.
- W2000295352 creator A5089227561 @default.
- W2000295352 date "2010-10-19" @default.
- W2000295352 modified "2023-10-10" @default.
- W2000295352 title "Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme" @default.
- W2000295352 cites W1505566296 @default.
- W2000295352 cites W1591986747 @default.
- W2000295352 cites W1601402644 @default.
- W2000295352 cites W1607295833 @default.
- W2000295352 cites W1970795622 @default.
- W2000295352 cites W1971855284 @default.
- W2000295352 cites W1981822738 @default.
- W2000295352 cites W1982615613 @default.
- W2000295352 cites W1983921046 @default.
- W2000295352 cites W1984811742 @default.
- W2000295352 cites W1993630271 @default.
- W2000295352 cites W1994519007 @default.
- W2000295352 cites W1995541462 @default.
- W2000295352 cites W1996795546 @default.
- W2000295352 cites W1998300679 @default.
- W2000295352 cites W2013120462 @default.
- W2000295352 cites W2014882192 @default.
- W2000295352 cites W2020164587 @default.
- W2000295352 cites W2021624791 @default.
- W2000295352 cites W2022481460 @default.
- W2000295352 cites W2025143098 @default.
- W2000295352 cites W2035036165 @default.
- W2000295352 cites W2039222535 @default.
- W2000295352 cites W2042978261 @default.
- W2000295352 cites W2050077444 @default.
- W2000295352 cites W2050820037 @default.
- W2000295352 cites W2053315646 @default.
- W2000295352 cites W2053684471 @default.
- W2000295352 cites W2056176542 @default.
- W2000295352 cites W2058189238 @default.
- W2000295352 cites W2061814831 @default.
- W2000295352 cites W2075132326 @default.
- W2000295352 cites W2076127587 @default.
- W2000295352 cites W2076517751 @default.
- W2000295352 cites W2089412829 @default.
- W2000295352 cites W2092496829 @default.
- W2000295352 cites W2104057569 @default.
- W2000295352 cites W2107917285 @default.
- W2000295352 cites W2109906269 @default.
- W2000295352 cites W2117091440 @default.
- W2000295352 cites W2117176545 @default.
- W2000295352 cites W2129722588 @default.
- W2000295352 cites W2130892977 @default.
- W2000295352 cites W2148727539 @default.
- W2000295352 cites W2156700198 @default.
- W2000295352 cites W2157329817 @default.
- W2000295352 cites W2159833823 @default.
- W2000295352 cites W2163840855 @default.
- W2000295352 cites W2168808372 @default.
- W2000295352 cites W2416128265 @default.
- W2000295352 cites W4313333870 @default.
- W2000295352 cites W4313422358 @default.
- W2000295352 doi "https://doi.org/10.1038/emboj.2010.256" @default.
- W2000295352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3020635" @default.
- W2000295352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20959807" @default.
- W2000295352 hasPublicationYear "2010" @default.
- W2000295352 type Work @default.
- W2000295352 sameAs 2000295352 @default.
- W2000295352 citedByCount "122" @default.
- W2000295352 countsByYear W20002953522012 @default.
- W2000295352 countsByYear W20002953522013 @default.
- W2000295352 countsByYear W20002953522014 @default.
- W2000295352 countsByYear W20002953522015 @default.
- W2000295352 countsByYear W20002953522016 @default.
- W2000295352 countsByYear W20002953522017 @default.
- W2000295352 countsByYear W20002953522018 @default.
- W2000295352 countsByYear W20002953522019 @default.
- W2000295352 countsByYear W20002953522020 @default.
- W2000295352 countsByYear W20002953522021 @default.
- W2000295352 countsByYear W20002953522022 @default.
- W2000295352 countsByYear W20002953522023 @default.
- W2000295352 crossrefType "journal-article" @default.
- W2000295352 hasAuthorship W2000295352A5001883769 @default.
- W2000295352 hasAuthorship W2000295352A5013607512 @default.
- W2000295352 hasAuthorship W2000295352A5033409338 @default.
- W2000295352 hasAuthorship W2000295352A5038808458 @default.
- W2000295352 hasAuthorship W2000295352A5041615081 @default.
- W2000295352 hasAuthorship W2000295352A5043432385 @default.
- W2000295352 hasAuthorship W2000295352A5049387493 @default.
- W2000295352 hasAuthorship W2000295352A5051454827 @default.
- W2000295352 hasAuthorship W2000295352A5066886337 @default.