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- W2000297780 endingPage "1017" @default.
- W2000297780 startingPage "999" @default.
- W2000297780 abstract "Nitric oxide (NO(.)) is a reactive nitrogen radical produced by the NO synthase (NOS) enzymes; it affects a plethora of downstream physiological and pathological processes. The past two decades have seen an explosion in the understanding of the role of NO(.) biology, highlighting various protective and damaging modes of action. Much of the controversy surrounding the role of NO(.) relates to the differing concentrations generated by the three isoforms of NOS. Both calcium-dependent isoforms of the enzyme (endothelial and neuronal NOS) generate low-nanomolar/picomolar concentrations of NO(.). By contrast, the calcium-independent isoform (inducible NOS (iNOS)) generates high concentrations of NO(.), 2-3 orders of magnitude greater. This review summarizes the current literature in relation to iNOS gene therapy for the therapeutic benefit of various pathological conditions, including various states of vascular disease, wound healing, erectile dysfunction, renal dysfunction and oncology. The available data provide convincing evidence that manipulation of endogenous NO(.) using iNOS gene therapy can provide the basis for future clinical trials." @default.
- W2000297780 created "2016-06-24" @default.
- W2000297780 creator A5044268077 @default.
- W2000297780 creator A5080850326 @default.
- W2000297780 creator A5081151755 @default.
- W2000297780 creator A5089976556 @default.
- W2000297780 date "2008-08-01" @default.
- W2000297780 modified "2023-09-29" @default.
- W2000297780 title "Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions" @default.
- W2000297780 cites W1004999796 @default.
- W2000297780 cites W1506642042 @default.
- W2000297780 cites W1559221509 @default.
- W2000297780 cites W1560310146 @default.
- W2000297780 cites W1573977017 @default.
- W2000297780 cites W1579604458 @default.
- W2000297780 cites W1580172964 @default.
- W2000297780 cites W1586130277 @default.
- W2000297780 cites W1602056757 @default.
- W2000297780 cites W1606853210 @default.
- W2000297780 cites W1840943005 @default.
- W2000297780 cites W1901002830 @default.
- W2000297780 cites W1963729009 @default.
- W2000297780 cites W1964835987 @default.
- W2000297780 cites W1966726553 @default.
- W2000297780 cites W1967225427 @default.
- W2000297780 cites W1968283357 @default.
- W2000297780 cites W1968327566 @default.
- W2000297780 cites W1972331465 @default.
- W2000297780 cites W1973584204 @default.
- W2000297780 cites W1973737079 @default.
- W2000297780 cites W1975308859 @default.
- W2000297780 cites W1976308128 @default.
- W2000297780 cites W1977113550 @default.
- W2000297780 cites W1978221784 @default.
- W2000297780 cites W1978304885 @default.
- W2000297780 cites W1979521526 @default.
- W2000297780 cites W1982220916 @default.
- W2000297780 cites W1985424742 @default.
- W2000297780 cites W1986525923 @default.
- W2000297780 cites W1986836312 @default.
- W2000297780 cites W1988946212 @default.
- W2000297780 cites W1990406980 @default.
- W2000297780 cites W1991615080 @default.
- W2000297780 cites W1992870310 @default.
- W2000297780 cites W1993020801 @default.
- W2000297780 cites W1995484601 @default.
- W2000297780 cites W1995572986 @default.
- W2000297780 cites W2002528642 @default.
- W2000297780 cites W2002711015 @default.
- W2000297780 cites W2005658600 @default.
- W2000297780 cites W2006607634 @default.
- W2000297780 cites W2008323911 @default.
- W2000297780 cites W2008644469 @default.
- W2000297780 cites W2010020462 @default.
- W2000297780 cites W2012675518 @default.
- W2000297780 cites W2013173848 @default.
- W2000297780 cites W2013868082 @default.
- W2000297780 cites W2014423009 @default.
- W2000297780 cites W2014495927 @default.
- W2000297780 cites W2015776844 @default.
- W2000297780 cites W2020242649 @default.
- W2000297780 cites W2020685125 @default.
- W2000297780 cites W2021334430 @default.
- W2000297780 cites W2025739877 @default.
- W2000297780 cites W2028600721 @default.
- W2000297780 cites W2029491963 @default.
- W2000297780 cites W203004974 @default.
- W2000297780 cites W2030284078 @default.
- W2000297780 cites W2031629641 @default.
- W2000297780 cites W2033320084 @default.
- W2000297780 cites W2037755687 @default.
- W2000297780 cites W2037756986 @default.
- W2000297780 cites W2041075406 @default.
- W2000297780 cites W2041765744 @default.
- W2000297780 cites W2042593687 @default.
- W2000297780 cites W2045458278 @default.
- W2000297780 cites W2046452304 @default.
- W2000297780 cites W2046844548 @default.
- W2000297780 cites W2048543877 @default.
- W2000297780 cites W2049109647 @default.
- W2000297780 cites W2050195616 @default.
- W2000297780 cites W2054084083 @default.
- W2000297780 cites W2054614967 @default.
- W2000297780 cites W2057669683 @default.
- W2000297780 cites W2059085904 @default.
- W2000297780 cites W2060654428 @default.
- W2000297780 cites W2062809291 @default.
- W2000297780 cites W2063092179 @default.
- W2000297780 cites W2065156053 @default.
- W2000297780 cites W2068601566 @default.
- W2000297780 cites W2068733395 @default.
- W2000297780 cites W2068852865 @default.
- W2000297780 cites W2069077866 @default.
- W2000297780 cites W2069934899 @default.
- W2000297780 cites W2071800932 @default.
- W2000297780 cites W2071881477 @default.
- W2000297780 cites W2072088194 @default.
- W2000297780 cites W2072341206 @default.