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- W2000298473 abstract "In order to investigate SAR regarding glucose moiety in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on glucose was conducted to explore potential utility as a suitable replacement of glucose per se. Among the compounds prepared, deshydroxy 29 (IC50 = 7.01 nM) demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date. But, none of the compounds were better than the parent molecule 5 (IC50 = 1.75 nM)." @default.
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- W2000298473 date "2011-01-01" @default.
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- W2000298473 title "Exploration of SAR regarding glucose moiety in novel C-aryl glucoside inhibitors of SGLT2" @default.
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- W2000298473 doi "https://doi.org/10.1016/j.bmcl.2010.11.115" @default.
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