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- W2000299078 abstract "In 412 first-degree relatives of 101 Summary young survivors of myocardial infarction the mean levels of serum-cholesterol and serum-triglyceride were significantly higher than in a control population but less than in the index patients. Hypercholesterolæmia (type IIa) occurred 1·8 times, hypertriglyceridæmia (type IV) 1·3 times, and combined hyperlipidæmia (type IIb) 2·5 times more commonly in relatives than in controls. There was little difference between the rates of hyperlipidæmia in the families of normolipidæmic and hyperlipidæmic probands. There was significant clustering of hyperlipoproteinæmia in thirty-three of the hundred and one families examined. Of these, only nine families had a single-type disease. Familial hypercholesterolæmia (type-IIa disease) was reported in 6% of families. In twenty-four families several abnormal lipoprotein phenotypes coexisted and half the members of these families were affected. A rather specific marker of this multiple-type familial hyperlipoproteinæmia was the presence of phenotype IIb, which was six times more common in first-degree relatives than in the control population. The results suggest that there is a familial trait of hyperlipidæmia in one-third of patients with premature coronary heart-disease, but it is not established whether the trait is inherited or produced by environmental factors." @default.
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- W2000299078 date "1973-05-01" @default.
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- W2000299078 title "FAMILY STUDY OF SERUM LIPIDS AND LIPOPROTEINS IN CORONARY HEART-DISEASE" @default.
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- W2000299078 doi "https://doi.org/10.1016/s0140-6736(73)91598-5" @default.
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