Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000299364> ?p ?o ?g. }
- W2000299364 endingPage "432" @default.
- W2000299364 startingPage "418" @default.
- W2000299364 abstract "The basic conclusions in almost all reports on new drug applications and in all publications in toxicology are based on statistical methods. However, serious contradictions exist in practice: designs with small samples sizes but use of asymptotic methods (i.e. constructed for larger sample sizes), statistically significant findings without biological relevance (and vice versa), proof of hazard vs. proof of safety, testing (e.g. no observed effect level) vs. estimation (e.g. benchmark dose), available statistical theory vs. related user-friendly software. In this review the biostatistical developments since about the year 2000 onwards are discussed, mainly structured for repeated-dose studies, mutagenicity, carcinogenicity, reproductive and ecotoxicological assays. A critical discussion is included on the unnecessarily conservative evaluation proposed in guidelines, the inadequate but almost always used proof of hazard approach, and the limitation of data-dependent decision-tree approaches." @default.
- W2000299364 created "2016-06-24" @default.
- W2000299364 creator A5065672865 @default.
- W2000299364 date "2014-08-08" @default.
- W2000299364 modified "2023-10-18" @default.
- W2000299364 title "Statistical evaluation of toxicological bioassays – a review" @default.
- W2000299364 cites W1238260143 @default.
- W2000299364 cites W1278996182 @default.
- W2000299364 cites W1494606261 @default.
- W2000299364 cites W1507283988 @default.
- W2000299364 cites W1563065811 @default.
- W2000299364 cites W1563067917 @default.
- W2000299364 cites W1591021879 @default.
- W2000299364 cites W1597179365 @default.
- W2000299364 cites W1818705401 @default.
- W2000299364 cites W1924092900 @default.
- W2000299364 cites W1927651106 @default.
- W2000299364 cites W1932066975 @default.
- W2000299364 cites W1964255162 @default.
- W2000299364 cites W1965053379 @default.
- W2000299364 cites W1965774655 @default.
- W2000299364 cites W1966824719 @default.
- W2000299364 cites W1968549819 @default.
- W2000299364 cites W1969503519 @default.
- W2000299364 cites W1969549835 @default.
- W2000299364 cites W1969649797 @default.
- W2000299364 cites W1969781406 @default.
- W2000299364 cites W1970526516 @default.
- W2000299364 cites W1970528088 @default.
- W2000299364 cites W1971214682 @default.
- W2000299364 cites W1972026402 @default.
- W2000299364 cites W1973044893 @default.
- W2000299364 cites W1973430195 @default.
- W2000299364 cites W1973458962 @default.
- W2000299364 cites W1978029054 @default.
- W2000299364 cites W1978262061 @default.
- W2000299364 cites W1979166475 @default.
- W2000299364 cites W1979279978 @default.
- W2000299364 cites W1980039530 @default.
- W2000299364 cites W1983737046 @default.
- W2000299364 cites W1986318366 @default.
- W2000299364 cites W1987717575 @default.
- W2000299364 cites W1988283995 @default.
- W2000299364 cites W1990065954 @default.
- W2000299364 cites W1990192366 @default.
- W2000299364 cites W1991143793 @default.
- W2000299364 cites W1991671862 @default.
- W2000299364 cites W1992225069 @default.
- W2000299364 cites W1992383645 @default.
- W2000299364 cites W1993547444 @default.
- W2000299364 cites W1993607221 @default.
- W2000299364 cites W1997278096 @default.
- W2000299364 cites W2000567608 @default.
- W2000299364 cites W2000573579 @default.
- W2000299364 cites W2000942157 @default.
- W2000299364 cites W2002215420 @default.
- W2000299364 cites W2002933971 @default.
- W2000299364 cites W2003060790 @default.
- W2000299364 cites W2003111395 @default.
- W2000299364 cites W2003692821 @default.
- W2000299364 cites W2003797712 @default.
- W2000299364 cites W2005086544 @default.
- W2000299364 cites W2005365030 @default.
- W2000299364 cites W2009470745 @default.
- W2000299364 cites W2010880541 @default.
- W2000299364 cites W2012496151 @default.
- W2000299364 cites W2013036967 @default.
- W2000299364 cites W2015883310 @default.
- W2000299364 cites W2016096489 @default.
- W2000299364 cites W2016185211 @default.
- W2000299364 cites W2016187967 @default.
- W2000299364 cites W2016610797 @default.
- W2000299364 cites W2018610988 @default.
- W2000299364 cites W2021974507 @default.
- W2000299364 cites W2023842585 @default.
- W2000299364 cites W2024259619 @default.
- W2000299364 cites W2024276652 @default.
- W2000299364 cites W2025172337 @default.
- W2000299364 cites W2026612111 @default.
- W2000299364 cites W2033834821 @default.
- W2000299364 cites W2034010632 @default.
- W2000299364 cites W2034912498 @default.
- W2000299364 cites W2037150236 @default.
- W2000299364 cites W2038064558 @default.
- W2000299364 cites W2039259455 @default.
- W2000299364 cites W2040029796 @default.
- W2000299364 cites W2042217402 @default.
- W2000299364 cites W2043903502 @default.
- W2000299364 cites W2044171889 @default.
- W2000299364 cites W2044456101 @default.
- W2000299364 cites W2044604222 @default.
- W2000299364 cites W2050207700 @default.
- W2000299364 cites W2050241533 @default.
- W2000299364 cites W2050854140 @default.
- W2000299364 cites W2050930135 @default.
- W2000299364 cites W2051754083 @default.
- W2000299364 cites W2052260016 @default.
- W2000299364 cites W2055992413 @default.