FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000300891> ?p ?o ?g. }

• W2000300891 endingPage "113" @default.
• W2000300891 startingPage "107" @default.
• W2000300891 abstract "A peptide ending with RFamide (Arg-Phe-amide) was discovered independently by three different laboratories in 2003 and named 26RFa or QRFP. In mammals, a longer version of the peptide, 43 amino acids, was identified and found to bind to the orphan G protein-coupled receptor GPR103. We searched the genome database of Branchiostoma floridae (Bfl) for receptor sequences related to those that bind peptides ending with RFa or RYa (including receptors for NPFF, PRLH, GnIH, and NPY). One receptor clustered in phylogenetic analyses with mammalian QRFP receptors. The gene has 3 introns in Bfl and 5 in human, but all intron positions differ, implying that the introns were inserted independently. A QRFP-like peptide consisting of 25 amino acids and ending with RFa was identified in the amphioxus genome. Eight of the ten last amino acids are identical between Bfl and human. The prepro-QRFP gene in Bfl has one intron in the propeptide whereas the human gene lacks introns. The Bfl QRFP peptide was synthesized and the receptor was functionally expressed in human cells. The response was measured as inositol phosphate (IP) turnover. The Bfl QRFP peptide was found to potently stimulate the receptor’s ability to induce IP turnover with an EC50 of 0.28 nM. Also the human QRFP peptides with 26 and 43 amino acids were found to stimulate the receptor (1.9 and 5.1 nM, respectively). Human QRFP with 26 amino acids without the carboxyterminal amide had dramatically lower potency at 1.3 μM. Thus, we have identified an amphioxus QRFP-related peptide and a corresponding receptor and shown that they interact to give a functional response." @default.
• W2000300891 created "2016-06-24" @default.
• W2000300891 creator A5003657445 @default.
• W2000300891 creator A5015125277 @default.
• W2000300891 creator A5030574661 @default.
• W2000300891 creator A5048552837 @default.
• W2000300891 creator A5054554158 @default.
• W2000300891 creator A5061245649 @default.
• W2000300891 creator A5088664449 @default.
• W2000300891 date "2015-01-01" @default.
• W2000300891 modified "2023-09-23" @default.
• W2000300891 title "Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae" @default.
• W2000300891 cites W1487776394 @default.
• W2000300891 cites W1764472238 @default.
• W2000300891 cites W1774444115 @default.
• W2000300891 cites W1968582019 @default.
• W2000300891 cites W1969441974 @default.
• W2000300891 cites W1984134771 @default.
• W2000300891 cites W2001362474 @default.
• W2000300891 cites W2001936817 @default.
• W2000300891 cites W2015865718 @default.
• W2000300891 cites W2024900444 @default.
• W2000300891 cites W2026333686 @default.
• W2000300891 cites W2029661560 @default.
• W2000300891 cites W2037462455 @default.
• W2000300891 cites W2044536055 @default.
• W2000300891 cites W2045947576 @default.
• W2000300891 cites W2045977811 @default.
• W2000300891 cites W2053441896 @default.
• W2000300891 cites W2071326593 @default.
• W2000300891 cites W2073195635 @default.
• W2000300891 cites W2075164158 @default.
• W2000300891 cites W2085919691 @default.
• W2000300891 cites W2086745052 @default.
• W2000300891 cites W2092472523 @default.
• W2000300891 cites W2094885706 @default.
• W2000300891 cites W2097961893 @default.
• W2000300891 cites W2111211467 @default.
• W2000300891 cites W2120772351 @default.
• W2000300891 cites W2131266487 @default.
• W2000300891 cites W2131871062 @default.
• W2000300891 cites W2137015675 @default.
• W2000300891 cites W2158477075 @default.
• W2000300891 cites W2166652281 @default.
• W2000300891 cites W2169501660 @default.
• W2000300891 cites W2169809697 @default.
• W2000300891 cites W2312726874 @default.
• W2000300891 doi "https://doi.org/10.1016/j.ygcen.2014.10.010" @default.
• W2000300891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25449662" @default.
• W2000300891 hasPublicationYear "2015" @default.
• W2000300891 type Work @default.
• W2000300891 sameAs 2000300891 @default.
• W2000300891 citedByCount "7" @default.
• W2000300891 countsByYear W20003008912015 @default.
• W2000300891 countsByYear W20003008912016 @default.
• W2000300891 countsByYear W20003008912017 @default.
• W2000300891 countsByYear W20003008912018 @default.
• W2000300891 countsByYear W20003008912020 @default.
• W2000300891 crossrefType "journal-article" @default.
• W2000300891 hasAuthorship W2000300891A5003657445 @default.
• W2000300891 hasAuthorship W2000300891A5015125277 @default.
• W2000300891 hasAuthorship W2000300891A5030574661 @default.
• W2000300891 hasAuthorship W2000300891A5048552837 @default.
• W2000300891 hasAuthorship W2000300891A5054554158 @default.
• W2000300891 hasAuthorship W2000300891A5061245649 @default.
• W2000300891 hasAuthorship W2000300891A5088664449 @default.
• W2000300891 hasConcept C104317684 @default.
• W2000300891 hasConcept C134018914 @default.
• W2000300891 hasConcept C170493617 @default.
• W2000300891 hasConcept C2779281246 @default.
• W2000300891 hasConcept C515207424 @default.
• W2000300891 hasConcept C54355233 @default.
• W2000300891 hasConcept C55493867 @default.
• W2000300891 hasConcept C86803240 @default.
• W2000300891 hasConcept C94671646 @default.
• W2000300891 hasConceptScore W2000300891C104317684 @default.
• W2000300891 hasConceptScore W2000300891C134018914 @default.
• W2000300891 hasConceptScore W2000300891C170493617 @default.
• W2000300891 hasConceptScore W2000300891C2779281246 @default.
• W2000300891 hasConceptScore W2000300891C515207424 @default.
• W2000300891 hasConceptScore W2000300891C54355233 @default.
• W2000300891 hasConceptScore W2000300891C55493867 @default.
• W2000300891 hasConceptScore W2000300891C86803240 @default.
• W2000300891 hasConceptScore W2000300891C94671646 @default.
• W2000300891 hasFunder F4320322581 @default.
• W2000300891 hasLocation W20003008911 @default.
• W2000300891 hasLocation W20003008912 @default.
• W2000300891 hasLocation W20003008913 @default.
• W2000300891 hasOpenAccess W2000300891 @default.
• W2000300891 hasPrimaryLocation W20003008911 @default.
• W2000300891 hasRelatedWork W2039352533 @default.
• W2000300891 hasRelatedWork W2041335525 @default.
• W2000300891 hasRelatedWork W2072834586 @default.
• W2000300891 hasRelatedWork W2076991776 @default.
• W2000300891 hasRelatedWork W2081600652 @default.
• W2000300891 hasRelatedWork W2092554027 @default.
• W2000300891 hasRelatedWork W2109717569 @default.
• W2000300891 hasRelatedWork W2334012009 @default.

• next