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• W2000301418 endingPage "1348" @default.
• W2000301418 startingPage "1335" @default.
• W2000301418 abstract "ABSTRACT One of the central regulators of oxidative stress in Saccharomyces cerevisiae is Yap1, a bZIP transcription factor of the AP-1 family. In unstressed cells, Yap1 is reduced and cytoplasmic, but in response to oxidative stress, it becomes oxidized and accumulates in the nucleus. To date, there have been no reports on the role of AP-1-like transcription factors in symbiotic fungi. An ortholog of Yap1, named YapA, was identified in the genome of the grass symbiont Epichloë festucae and shown to complement an S. cerevisiae Δ yap1 mutant. Hyphae of the E. festucae Δ yapA strain were sensitive to menadione and diamide but resistant to H 2 O 2 , KO 2 , and tert -butyl hydroperoxide ( t -BOOH). In contrast, conidia of the Δ yapA strain were very sensitive to H 2 O 2 and failed to germinate. Using a P catA-eGFP degron-tagged reporter, YapA was shown to be required for expression of a spore-specific catalase gene, catA . Although YapA-EGFP localized to the nucleus in response to host reactive oxygen species during seedling infection, there was no difference in whole-plant and cellular phenotypes of plants infected with the Δ yapA strain compared to the wild-type strain. Homologs of the S. cerevisiae and Schizosaccharomyces pombe redox-sensing proteins (Gpx3 and Tpx1, respectively) did not act as redox sensors for YapA in E. festucae . In response to oxidative stress, YapA-EGFP localized to the nuclei of E. festucae Δ gpxC , Δ tpxA , and Δ gpxC Δ tpxA cells to the same degree as that in wild-type cells. These results show that E. festucae has a robust system for countering oxidative stress in culture and in planta but that Gpx3- or Tpx1-like thiol peroxidases are dispensable for activation of YapA." @default.
• W2000301418 created "2016-06-24" @default.
• W2000301418 creator A5060154827 @default.
• W2000301418 creator A5085346682 @default.
• W2000301418 date "2013-10-01" @default.
• W2000301418 modified "2023-09-27" @default.
• W2000301418 title "Redox Regulation of an AP-1-Like Transcription Factor, YapA, in the Fungal Symbiont Epichloë festucae" @default.
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• W2000301418 doi "https://doi.org/10.1128/ec.00129-13" @default.
• W2000301418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3811341" @default.
• W2000301418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23893078" @default.
• W2000301418 hasPublicationYear "2013" @default.
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