FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000301446> ?p ?o ?g. }

• W2000301446 endingPage "403" @default.
• W2000301446 startingPage "397" @default.
• W2000301446 abstract "Strains of Neisseria gonorrhoeae were used to evaluate bactericidal and opsonic properties of McAb 10 directed against the Neisserial outer membrane antigen, H.8. Gonococci were either serum resistant in the absence but serum sensitive in the presence, of McAb 10, or serum sensitive or serum resistant regardless of the presence of McAb 10. Strain JS3, which fell in the former category, was used in subsequent studies. C1 zymogen formed by reassociation of isolated C1 subunits was not directly activated by JS3 in the presence or absence of C1-inhibitor. JS3 thus was unable to directly activate the classical pathway independently of antibody. When purified classical pathway components were used to deposit C3 on JS3 in the absence of serum regulatory proteins or antibodies, added C1-inhibitor reduced C3 binding to background levels. When McAb 10 was present, C3 binding was unaffected by C1-inhibitor. Covalently bound, large molecular weight C3 alpha-chain-gonococcal complexes were disbanded by methylamine release of ester linkages. Released 125I-C3 migrated as C3b without degradation by gonococcal proteases. Purified classical components alone or McAb 10 alone facilitated JS3 killing by neutrophils; when combined, the two provided maximal killing. Levels of McAb 10 that only slightly increase C3 deposition on JS3 are bactericidal in serum and maximally opsonic in combination with purified classical pathway components." @default.
• W2000301446 created "2016-06-24" @default.
• W2000301446 creator A5003532293 @default.
• W2000301446 creator A5009926216 @default.
• W2000301446 creator A5021921548 @default.
• W2000301446 creator A5028399643 @default.
• W2000301446 creator A5034468688 @default.
• W2000301446 creator A5082148123 @default.
• W2000301446 date "1989-02-01" @default.
• W2000301446 modified "2023-10-12" @default.
• W2000301446 title "Interaction of Neisseria gonorrhoeae with classical complement components, C1-inhibitor, and a monoclonal antibody directed against the Neisserial H.8 antigen." @default.
• W2000301446 cites W1480926422 @default.
• W2000301446 cites W1502671196 @default.
• W2000301446 cites W1525730872 @default.
• W2000301446 cites W1531382224 @default.
• W2000301446 cites W1562562544 @default.
• W2000301446 cites W1564054636 @default.
• W2000301446 cites W1568481877 @default.
• W2000301446 cites W1632723277 @default.
• W2000301446 cites W1641905191 @default.
• W2000301446 cites W1676393068 @default.
• W2000301446 cites W1750480586 @default.
• W2000301446 cites W1781864281 @default.
• W2000301446 cites W1836182851 @default.
• W2000301446 cites W183757317 @default.
• W2000301446 cites W1859635247 @default.
• W2000301446 cites W1894781817 @default.
• W2000301446 cites W1910217022 @default.
• W2000301446 cites W1913637073 @default.
• W2000301446 cites W1937099844 @default.
• W2000301446 cites W1943309494 @default.
• W2000301446 cites W1979526054 @default.
• W2000301446 cites W1999204432 @default.
• W2000301446 cites W2012113843 @default.
• W2000301446 cites W2018289835 @default.
• W2000301446 cites W2023050714 @default.
• W2000301446 cites W2023667450 @default.
• W2000301446 cites W2027382705 @default.
• W2000301446 cites W2036667365 @default.
• W2000301446 cites W2041264310 @default.
• W2000301446 cites W2043865219 @default.
• W2000301446 cites W2081807824 @default.
• W2000301446 cites W2100837269 @default.
• W2000301446 cites W2111724437 @default.
• W2000301446 cites W2120386201 @default.
• W2000301446 cites W2124941807 @default.
• W2000301446 cites W2142706301 @default.
• W2000301446 cites W2147518934 @default.
• W2000301446 cites W2154744978 @default.
• W2000301446 cites W2167124371 @default.
• W2000301446 cites W2169339414 @default.
• W2000301446 cites W2170808571 @default.
• W2000301446 cites W2282935375 @default.
• W2000301446 cites W2321064560 @default.
• W2000301446 cites W2398399906 @default.
• W2000301446 cites W2418817768 @default.
• W2000301446 cites W54530014 @default.
• W2000301446 cites W2154057465 @default.
• W2000301446 doi "https://doi.org/10.1172/jci113897" @default.
• W2000301446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303694" @default.
• W2000301446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2492308" @default.
• W2000301446 hasPublicationYear "1989" @default.
• W2000301446 type Work @default.
• W2000301446 sameAs 2000301446 @default.
• W2000301446 citedByCount "13" @default.
• W2000301446 countsByYear W20003014462016 @default.
• W2000301446 countsByYear W20003014462017 @default.
• W2000301446 countsByYear W20003014462018 @default.
• W2000301446 crossrefType "journal-article" @default.
• W2000301446 hasAuthorship W2000301446A5003532293 @default.
• W2000301446 hasAuthorship W2000301446A5009926216 @default.
• W2000301446 hasAuthorship W2000301446A5021921548 @default.
• W2000301446 hasAuthorship W2000301446A5028399643 @default.
• W2000301446 hasAuthorship W2000301446A5034468688 @default.
• W2000301446 hasAuthorship W2000301446A5082148123 @default.
• W2000301446 hasBestOaLocation W20003014461 @default.
• W2000301446 hasConcept C111684460 @default.
• W2000301446 hasConcept C147483822 @default.
• W2000301446 hasConcept C153911025 @default.
• W2000301446 hasConcept C159654299 @default.
• W2000301446 hasConcept C171279029 @default.
• W2000301446 hasConcept C181199279 @default.
• W2000301446 hasConcept C182220744 @default.
• W2000301446 hasConcept C185592680 @default.
• W2000301446 hasConcept C189446657 @default.
• W2000301446 hasConcept C203014093 @default.
• W2000301446 hasConcept C2777954195 @default.
• W2000301446 hasConcept C2778775115 @default.
• W2000301446 hasConcept C2779166590 @default.
• W2000301446 hasConcept C523546767 @default.
• W2000301446 hasConcept C542903549 @default.
• W2000301446 hasConcept C54355233 @default.
• W2000301446 hasConcept C55493867 @default.
• W2000301446 hasConcept C86803240 @default.
• W2000301446 hasConcept C89372155 @default.
• W2000301446 hasConcept C89423630 @default.
• W2000301446 hasConcept C91523082 @default.
• W2000301446 hasConceptScore W2000301446C111684460 @default.

• next