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- W2000302343 abstract "TRIM8 is a member of the protein family defined by the presence of a common domain structure composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8 cancels the negative effect of PIAS3 on STAT3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Furthermore, expression of TRIM8 in NIH3T3 cells enhances Src-dependent tumorigenesis. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3." @default.
- W2000302343 created "2016-06-24" @default.
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- W2000302343 date "2010-07-01" @default.
- W2000302343 modified "2023-10-16" @default.
- W2000302343 title "TRIM8 modulates STAT3 activity through negative regulation of PIAS3" @default.
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- W2000302343 doi "https://doi.org/10.1242/jcs.068981" @default.
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