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• W2000302804 abstract "mTOR (mammalian target of rapamycin) is a highly conserved serine/threonine protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors (in particular insulin and insulin-like growth factors), nutrients and cellular stresses, some of the mechanisms involved are still poorly understood. Recent work has implicated mTOR in a variety of important human pathologies, including cancer, Type 2 diabetes and neurodegenerative disorders, heightening interest and accelerating progress in dissecting out the control and functions of mTOR." @default.
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• W2000302804 date "2009-01-20" @default.
• W2000302804 modified "2023-09-27" @default.
• W2000302804 title "mTOR: dissecting regulation and mechanism of action to understand human disease" @default.
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• W2000302804 doi "https://doi.org/10.1042/bst0370213" @default.
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