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• W2000303677 startingPage "173" @default.
• W2000303677 abstract "Harman's free radical theory of aging posits that oxidized macromolecules accumulate with age to decrease function and shorten life-span. However, nutritional and genetic interventions to boost anti-oxidants have generally failed to increase life-span. Furthermore, the free radical theory fails to explain why exercise causes higher levels of oxyradical damage, but generally promotes healthy aging. The separate anti-aging paradigms of genetic or caloric reductions in the insulin signaling pathway is thought to slow the rate of living to reduce metabolism, but recent evidence from Westbrook and Bartke suggests metabolism actually increases in long-lived mice. To unify these disparate theories and data, here, we propose the epigenetic oxidative redox shift (EORS) theory of aging. According to EORS, sedentary behavior associated with age triggers an oxidized redox shift and impaired mitochondrial function. In order to maintain resting energy levels, aerobic glycolysis is upregulated by redox-sensitive transcription factors. As emphasized by DeGrey, the need to supply NAD(+) for glucose oxidation and maintain redox balance with impaired mitochondrial NADH oxidoreductase requires the upregulation of other oxidoreductases. In contrast to the 2% inefficiency of mitochondrial reduction of oxygen to the oxyradical, these other oxidoreductases enable glycolytic energy production with a deleterious 100% efficiency in generating oxyradicals. To avoid this catastrophic cycle, lactate dehydrogenase is upregulated at the expense of lactic acid acidosis. This metabolic shift is epigenetically enforced, as is insulin resistance to reduce mitochondrial turnover. The low mitochondrial capacity for efficient production of energy reinforces a downward spiral of more sedentary behavior leading to accelerated aging, increased organ failure with stress, impaired immune and vascular functions and brain aging. Several steps in the pathway are amenable to reversal for exit from the vicious cycle of EORS. Examples from our work in the aging rodent brain as well as other aging models are provided." @default.
• W2000303677 created "2016-06-24" @default.
• W2000303677 creator A5011704834 @default.
• W2000303677 date "2010-03-01" @default.
• W2000303677 modified "2023-09-23" @default.
• W2000303677 title "Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories" @default.
• W2000303677 cites W1484205189 @default.
• W2000303677 cites W1494066079 @default.
• W2000303677 cites W1558542135 @default.
• W2000303677 cites W1581565952 @default.
• W2000303677 cites W1719028472 @default.
• W2000303677 cites W1781453437 @default.
• W2000303677 cites W1863866282 @default.
• W2000303677 cites W1901844227 @default.
• W2000303677 cites W1922087192 @default.
• W2000303677 cites W1931843124 @default.
• W2000303677 cites W1964779097 @default.
• W2000303677 cites W1965108122 @default.
• W2000303677 cites W1967874462 @default.
• W2000303677 cites W1970240791 @default.
• W2000303677 cites W1973931485 @default.
• W2000303677 cites W1981540772 @default.
• W2000303677 cites W1983600166 @default.
• W2000303677 cites W1984042519 @default.
• W2000303677 cites W1990195300 @default.
• W2000303677 cites W1990916340 @default.
• W2000303677 cites W1991295740 @default.
• W2000303677 cites W1992049458 @default.
• W2000303677 cites W1993185646 @default.
• W2000303677 cites W1993774063 @default.
• W2000303677 cites W1994946767 @default.
• W2000303677 cites W1995266526 @default.
• W2000303677 cites W1995653643 @default.
• W2000303677 cites W1996797097 @default.
• W2000303677 cites W2003064131 @default.
• W2000303677 cites W2004442859 @default.
• W2000303677 cites W2005586848 @default.
• W2000303677 cites W2009609804 @default.
• W2000303677 cites W2010065060 @default.
• W2000303677 cites W2010510740 @default.
• W2000303677 cites W2011397216 @default.
• W2000303677 cites W2020089910 @default.
• W2000303677 cites W2020506420 @default.
• W2000303677 cites W2022075548 @default.
• W2000303677 cites W2022868326 @default.
• W2000303677 cites W2024956005 @default.
• W2000303677 cites W2025028134 @default.
• W2000303677 cites W2028545299 @default.
• W2000303677 cites W2029223147 @default.
• W2000303677 cites W2030199991 @default.
• W2000303677 cites W2033573102 @default.
• W2000303677 cites W2035597104 @default.
• W2000303677 cites W2036420941 @default.
• W2000303677 cites W2038770231 @default.
• W2000303677 cites W2040306513 @default.
• W2000303677 cites W2047806321 @default.
• W2000303677 cites W2053133117 @default.
• W2000303677 cites W2055364952 @default.
• W2000303677 cites W2055708395 @default.
• W2000303677 cites W2059415866 @default.
• W2000303677 cites W2060221033 @default.
• W2000303677 cites W2064861163 @default.
• W2000303677 cites W2067279987 @default.
• W2000303677 cites W2069988949 @default.
• W2000303677 cites W2072039135 @default.
• W2000303677 cites W2073546855 @default.
• W2000303677 cites W2074740541 @default.
• W2000303677 cites W2079803075 @default.
• W2000303677 cites W2081397294 @default.
• W2000303677 cites W2089022581 @default.
• W2000303677 cites W2090760765 @default.
• W2000303677 cites W2097369775 @default.
• W2000303677 cites W2098689751 @default.
• W2000303677 cites W2100622640 @default.
• W2000303677 cites W2102507011 @default.
• W2000303677 cites W2103416697 @default.
• W2000303677 cites W2103700558 @default.
• W2000303677 cites W2105303800 @default.
• W2000303677 cites W2107496637 @default.
• W2000303677 cites W2107547700 @default.
• W2000303677 cites W2109147159 @default.
• W2000303677 cites W2113529945 @default.
• W2000303677 cites W2116503116 @default.
• W2000303677 cites W2117517043 @default.
• W2000303677 cites W2117879192 @default.
• W2000303677 cites W2128188444 @default.
• W2000303677 cites W2134555277 @default.
• W2000303677 cites W2137720344 @default.
• W2000303677 cites W2137999257 @default.
• W2000303677 cites W2139362558 @default.
• W2000303677 cites W2140715527 @default.
• W2000303677 cites W2144699106 @default.
• W2000303677 cites W2147993424 @default.
• W2000303677 cites W2154719999 @default.
• W2000303677 cites W2155914183 @default.
• W2000303677 cites W2160420618 @default.
• W2000303677 cites W2161162275 @default.
• W2000303677 cites W2161532608 @default.

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