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- W2000304043 abstract "Abstract The existence of immunity in human schistosomiasis is based essentially on indirect evidence. In order to obtain more direct information a passive transfer study was performed. Gamma globulin prepared from the serum of 45 adults from St. Lucia, West Indies, with proved schistosomiasis mansoni (SGG) was administered in massive doses to 6 young St. Lucian children (mean age under 5) with established infections. Matched controls received pooled human gamma globulin obtained from donors in the continental United States of America (CGG). The SGG had high antischistosomal antibody titres while the CGG had none. Children treated with SGG had increases in antischistosomal antibody titres and in immediate but not delayed skin test reactivity to schistosome antigens. SGG had no effect on faecal egg excretion in the infected children either in comparison with their own output before treatment or with that of matched controls treated with CGG. Studies are now in progress on the effects of repeated administration of SGG and CGG to uninfected children in a high incidence area." @default.
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- W2000304043 date "1972-01-01" @default.
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- W2000304043 title "Passive transfer of immunity in human schistosomiasis mansoni: Effect of hyperimmune anti-schistosome gamma globulin on early established infections" @default.
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- W2000304043 doi "https://doi.org/10.1016/0035-9203(72)90054-5" @default.
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