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- W2000304382 abstract "Kinesin superfamily proteins (KIFs) are molecular motors that typically alter the subcellular localization of their cargos. However, the atypical kinesin KIF26A does not serve as a motor but can bind microtubules and affect cellular signaling cascades. Here, we show that KIF26A maintains intracellular calcium homeostasis and negatively regulates nociceptive sensation. Kif26a−/− mice exhibit intense and prolonged nociceptive responses. In their primary sensory neurons, excessive inhibitory phosphorylation of plasma membrane Ca2+ ATPase (PMCA) mediated by focal adhesion kinase (FAK) rendered the Ca transients resistant to termination, and the peripheral axonal outgrowth was significantly enhanced. Upstream, KIF26A is directly associated with a FERM domain of FAK and antagonizes FAK function in integrin-Src family kinase (SFK)-FAK signaling, possibly through steric hindrance and localization to cytoplasmic microtubules." @default.
- W2000304382 created "2016-06-24" @default.
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- W2000304382 date "2006-04-01" @default.
- W2000304382 modified "2023-10-18" @default.
- W2000304382 title "The Wnt signaling pathway: A focus on its role in establishing polarity of cells, tissues and organs" @default.
- W2000304382 doi "https://doi.org/10.1016/j.semcdb.2006.05.008" @default.
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