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• W2000304849 abstract "The role of iron in the growth and metabolism of M. tuberculosis and other mycobacteria is discussed in relation to the acquisiton of iron from host sources, such as transferrin, lactoferrin and ferritin, and its subsequent assimilation and utilization by the bacteria. Key components involved in the acquisition of iron (as ferric ion) and its initial transport into the mycobacterial cell are extracellular iron binding agents (siderophores) which, in pathogenic mycobacteria, are the carboxymycobactins and, in saprophytic mycobacteria, are the exochelins. In both cases, iron may be transferred to an intra-envelope, short-term storage molecule, mycobactin. For transport across the cell membrane, a reductase is used which converts FeIII-mycobactin to the FeII form. The ferrous ion, possibly complexed with salicylic acid, is then shuttled across the membrane either for direct incorporation into various porphyrins and apoproteins or, for storage of iron within the bacterial cytoplasm, bacterioferritin. The overall process of iron acquisition and its utilization is under very genetic tight control. The importance of iron in the virulence of mycobacteria is discussed in relationship to the development of tuberculosis. The management of dietary iron can therefore be influential in aiding the outcome of this disease. The role of the old anti-TB compound, p-aminosalicylate (PAS), is discussed in its action as an inhibitor of iron assimilation, together with the prospects of being able to synthesize further selective inhibitors of iron metabolism that may be useful as future chemotherapeutic agents." @default.
• W2000304849 created "2016-06-24" @default.
• W2000304849 creator A5084715302 @default.
• W2000304849 date "2004-01-01" @default.
• W2000304849 modified "2023-10-04" @default.
• W2000304849 title "Iron, mycobacteria and tuberculosis" @default.
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• W2000304849 cites W1596216202 @default.
• W2000304849 cites W1616445519 @default.
• W2000304849 cites W171830581 @default.
• W2000304849 cites W183157429 @default.
• W2000304849 cites W1846680989 @default.
• W2000304849 cites W1857022456 @default.
• W2000304849 cites W1903814430 @default.
• W2000304849 cites W1926542160 @default.
• W2000304849 cites W1967581313 @default.
• W2000304849 cites W1974174816 @default.
• W2000304849 cites W1975504944 @default.
• W2000304849 cites W1975813672 @default.
• W2000304849 cites W1980530950 @default.
• W2000304849 cites W1981833749 @default.
• W2000304849 cites W1987578347 @default.
• W2000304849 cites W1987722702 @default.
• W2000304849 cites W1989175728 @default.
• W2000304849 cites W1990083588 @default.
• W2000304849 cites W1992276931 @default.
• W2000304849 cites W1997714940 @default.
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• W2000304849 cites W2005793913 @default.
• W2000304849 cites W2006869613 @default.
• W2000304849 cites W2008410877 @default.
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• W2000304849 cites W2022945159 @default.
• W2000304849 cites W2027276229 @default.
• W2000304849 cites W2028133510 @default.
• W2000304849 cites W2029506941 @default.
• W2000304849 cites W2030633873 @default.
• W2000304849 cites W2038031211 @default.
• W2000304849 cites W2039638650 @default.
• W2000304849 cites W2044789592 @default.
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• W2000304849 cites W2047815418 @default.
• W2000304849 cites W2049426660 @default.
• W2000304849 cites W2057067365 @default.
• W2000304849 cites W2059750112 @default.
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• W2000304849 cites W2073761400 @default.
• W2000304849 cites W2074419195 @default.
• W2000304849 cites W2081857020 @default.
• W2000304849 cites W2082915790 @default.
• W2000304849 cites W2088167775 @default.
• W2000304849 cites W2096089776 @default.
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• W2000304849 cites W2150689174 @default.
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• W2000304849 cites W2165273016 @default.
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• W2000304849 cites W2241346466 @default.
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• W2000304849 cites W2327117766 @default.
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• W2000304849 doi "https://doi.org/10.1016/j.tube.2003.08.012" @default.
• W2000304849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14670352" @default.
• W2000304849 hasPublicationYear "2004" @default.
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