Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000305237> ?p ?o ?g. }
- W2000305237 endingPage "652" @default.
- W2000305237 startingPage "635" @default.
- W2000305237 abstract "Psoriasis is a T-cell mediated autoimmune inflammatory skin disease recognized by skin surface inflammation, epidermal proliferation, hyperkeratosis, angiogenesis and anomalous keratinization. Currently, various pharmacotherapies are available for it; however, pharmacotherapy based on conventional formulations can provide therapeutic benefits only to a limited extent. Recent advancement in nanotechnology-based nanomedicines has led to the possibility of improving the efficacy and safety of pharmacotherapeutic agents for psoriasis.This review covers the brief pathophysiology of psoriasis, available medications and its associated challenges in treatment. Collective accounts of various drugs acting on different molecular targets of psoriasis and the role of nanomedicines in their effective targeting are discussed. Moreover, newer approaches in psoriatic therapy such as combination drug targeting and physical techniques of topical permeation enhancement along with nanomedicines are also discussed.Novel nanomedicines (such as liposomes, polymeric nanoparticles, etc.) have shown their potential in improving therapeutic benefits of antipsoriatic drugs by increasing their therapeutic efficacy with minimal toxicity. Nevertheless, while the results on animal models using nanomedicine-based drug targeting of psoriasis via different route seem promising, lack of sufficient evidence in a clinical setup is a constraint and more clinical studies on the efficacy and safety of nanomedicines in psoriasis therapy are required." @default.
- W2000305237 created "2016-06-24" @default.
- W2000305237 creator A5026860535 @default.
- W2000305237 creator A5028490369 @default.
- W2000305237 creator A5041945418 @default.
- W2000305237 creator A5044356237 @default.
- W2000305237 creator A5061244523 @default.
- W2000305237 creator A5087908803 @default.
- W2000305237 date "2014-12-02" @default.
- W2000305237 modified "2023-09-30" @default.
- W2000305237 title "Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy" @default.
- W2000305237 cites W1586082586 @default.
- W2000305237 cites W1759473510 @default.
- W2000305237 cites W1861339113 @default.
- W2000305237 cites W1964227256 @default.
- W2000305237 cites W1967350651 @default.
- W2000305237 cites W1969253620 @default.
- W2000305237 cites W1969425571 @default.
- W2000305237 cites W1970472461 @default.
- W2000305237 cites W1972160113 @default.
- W2000305237 cites W1975168037 @default.
- W2000305237 cites W1975221395 @default.
- W2000305237 cites W1977624030 @default.
- W2000305237 cites W1980800108 @default.
- W2000305237 cites W1981636071 @default.
- W2000305237 cites W1982292637 @default.
- W2000305237 cites W1983643048 @default.
- W2000305237 cites W1983963285 @default.
- W2000305237 cites W1986557490 @default.
- W2000305237 cites W1989972996 @default.
- W2000305237 cites W1995995697 @default.
- W2000305237 cites W1996584137 @default.
- W2000305237 cites W2004468483 @default.
- W2000305237 cites W2006560775 @default.
- W2000305237 cites W2006803867 @default.
- W2000305237 cites W2010039501 @default.
- W2000305237 cites W2018317719 @default.
- W2000305237 cites W2023033089 @default.
- W2000305237 cites W2023944270 @default.
- W2000305237 cites W2025636925 @default.
- W2000305237 cites W2026438690 @default.
- W2000305237 cites W2027302175 @default.
- W2000305237 cites W2030986229 @default.
- W2000305237 cites W2031256542 @default.
- W2000305237 cites W2032004576 @default.
- W2000305237 cites W2033252275 @default.
- W2000305237 cites W2033815967 @default.
- W2000305237 cites W2033852473 @default.
- W2000305237 cites W2036515288 @default.
- W2000305237 cites W2038063038 @default.
- W2000305237 cites W2039309206 @default.
- W2000305237 cites W2040115324 @default.
- W2000305237 cites W2040685164 @default.
- W2000305237 cites W2040752439 @default.
- W2000305237 cites W2041277866 @default.
- W2000305237 cites W2042177184 @default.
- W2000305237 cites W2043894892 @default.
- W2000305237 cites W2045366993 @default.
- W2000305237 cites W2049178028 @default.
- W2000305237 cites W2049284566 @default.
- W2000305237 cites W2049453047 @default.
- W2000305237 cites W2050869709 @default.
- W2000305237 cites W2057141276 @default.
- W2000305237 cites W2058487327 @default.
- W2000305237 cites W2062742530 @default.
- W2000305237 cites W2067078308 @default.
- W2000305237 cites W2068089617 @default.
- W2000305237 cites W2073143004 @default.
- W2000305237 cites W2074718848 @default.
- W2000305237 cites W2080014602 @default.
- W2000305237 cites W2081986573 @default.
- W2000305237 cites W2082675655 @default.
- W2000305237 cites W2083340902 @default.
- W2000305237 cites W2084571636 @default.
- W2000305237 cites W2085357851 @default.
- W2000305237 cites W2085760714 @default.
- W2000305237 cites W2086614286 @default.
- W2000305237 cites W2088146841 @default.
- W2000305237 cites W2089257120 @default.
- W2000305237 cites W2092105570 @default.
- W2000305237 cites W2094672777 @default.
- W2000305237 cites W2097249053 @default.
- W2000305237 cites W2101586009 @default.
- W2000305237 cites W2101773814 @default.
- W2000305237 cites W2102109292 @default.
- W2000305237 cites W2105412466 @default.
- W2000305237 cites W2107432039 @default.
- W2000305237 cites W2110699664 @default.
- W2000305237 cites W2121469147 @default.
- W2000305237 cites W2121879427 @default.
- W2000305237 cites W2123158310 @default.
- W2000305237 cites W2123794877 @default.
- W2000305237 cites W2126102990 @default.
- W2000305237 cites W2133948824 @default.
- W2000305237 cites W2143973265 @default.
- W2000305237 cites W2144182791 @default.
- W2000305237 cites W2146128398 @default.
- W2000305237 cites W2319595723 @default.