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• W2000305368 abstract "The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg -1 . They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multifold. First, Tumor Necrosis Factor-alpha (TNFα) and Interleukin-1 (IL-1) release was markedly reduced by the agents. Second, high-affinity receptor binding on fibroblasts of TNFα and IL-1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo-oxygenase and leukotriene 5'-lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process." @default.
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• W2000305368 date "1996-09-01" @default.
• W2000305368 modified "2023-10-05" @default.
• W2000305368 title "The Anti-inflammatory Activiy of Metal Complexes of Heterocyclic Thiosemicarbazones, 2-Substituted PyridineN-Oxides and 2-Pyridylthioureas" @default.
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• W2000305368 doi "https://doi.org/10.1002/(sici)1099-0739(199609)10:7<485::aid-aoc504>3.0.co;2-#" @default.
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