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• W2000306578 abstract "Objective.Many studies have demonstrated that clinically evident tumor cells already carry multiple genetic alterations and further accumulation of genetic alteration causes tumor progression which plays a role in metastasis. Therefore, it could be expected that malignant potential in the metastatic site is more aggressive than that in the primary site. Using several immunohistochemical markers (p53, Ki-67, and CD44v6), we investigated an alteration of malignant potential. Methods.We immunohistochemically examined expression of p53, Ki-67, and CD44 in primary and metastatic lesions of ovarian cancer. Fifty-six samples of primary lesions and matched metastatic sites from 56 patients with primary epithelial ovarian cancers were included in this study. Results.In 16 cases (28%), the histological grade of the metastatic lesion increased. This difference was statistically significant (P= 0.0232). In 16 cases (28%), the expression of p53 increased in the metastatic lesions, in 5 pairs from negative to positive, whereas the case decrease in the metastatic lesions was only 1. This difference was statistically significant (P= 0.0046). There was no significant difference in Ki-67 labeling indices and expression of CD44v6 between the primary and matched metastatic lesions. The degree of p53 expression in the metastatic lesions significantly correlated with disease-free survival (P= 0.0482), whereas that in the primary lesions did not. Moreover, high p53 expression in the metastatic lesions significantly correlated with disease-free survival in multivariate analysis. Conclusions.The p53 expression in metastatic lesions may reflect an aggressive biologic behavior in ovarian cancer." @default.
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• W2000306578 date "1999-03-01" @default.
• W2000306578 modified "2023-09-25" @default.
• W2000306578 title "Comparison of p53, Ki-67, and CD44v6 Expression between Primary and Matched Metastatic Lesions in Ovarian Cancer" @default.
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• W2000306578 doi "https://doi.org/10.1006/gyno.1998.5266" @default.
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