FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000306855> ?p ?o ?g. }

• W2000306855 endingPage "794" @default.
• W2000306855 startingPage "784" @default.
• W2000306855 abstract "Abstract Cryolesion of the frontoparietal cortex in mice is a well‐described brain injury paradigm that results in increased astrogliosis surrounding the lesion site and is accompanied by a prominent increase in the MAO‐B levels in astrocytes. Whether these increased MAO‐B levels contribute to cellular damage or modulate reactive astrocytosis remains unclear. MAO‐B activity may contribute to cellular damage, since its metabolism products are highly toxic to the cells. Additionally, it has been suggested that MAO‐B inhibition may regulate astrocytic reaction. In this study, we have determined the relative contribution of MAO‐B activity to the outcome following freeze injury. Freeze injury induced a prominent increase of several inflammatory markers, including ICAM, Mac‐1, EB22, and GFAP. Inhibition of MAO‐B activity using the selective inhibitor PF9601N did not reduce this cryolesion‐induced inflammatory response. Additional data revealed that the expression of several cryolesion‐induced cell death genes, such as Fas, Rip, p53, and ICE, was not reduced in PF9601N‐treated mice, evidencing that MAO‐B activity did not contribute to cryolesion‐induced cell death. Definitive functional analysis of the mice using the ladder beam task revealed that MAO‐B inhibition did not improve the cryolesion‐induced motor impairment. These data strongly suggest that, although MAO‐B is highly expressed in the area surrounding the lesion site, its activity does not contribute to the cellular damage or play any role in regulating astrocytic reactivity. © 2008 Wiley‐Liss, Inc." @default.
• W2000306855 created "2016-06-24" @default.
• W2000306855 creator A5011542402 @default.
• W2000306855 creator A5028704915 @default.
• W2000306855 creator A5029281471 @default.
• W2000306855 creator A5030113409 @default.
• W2000306855 creator A5030666031 @default.
• W2000306855 creator A5090445763 @default.
• W2000306855 date "2008-10-01" @default.
• W2000306855 modified "2023-10-10" @default.
• W2000306855 title "Monoamine oxidase-B activity is not involved in the neuroinflammatory response elicited by a focal freeze brain injury" @default.
• W2000306855 cites W1601370958 @default.
• W2000306855 cites W1819159128 @default.
• W2000306855 cites W1905320291 @default.
• W2000306855 cites W1958939554 @default.
• W2000306855 cites W1964590338 @default.
• W2000306855 cites W1965933264 @default.
• W2000306855 cites W1967784617 @default.
• W2000306855 cites W1980234111 @default.
• W2000306855 cites W1983737685 @default.
• W2000306855 cites W1986193590 @default.
• W2000306855 cites W1991240905 @default.
• W2000306855 cites W1993370040 @default.
• W2000306855 cites W1993964261 @default.
• W2000306855 cites W1997414730 @default.
• W2000306855 cites W2005731110 @default.
• W2000306855 cites W2017281237 @default.
• W2000306855 cites W2017644891 @default.
• W2000306855 cites W2024770800 @default.
• W2000306855 cites W2026136779 @default.
• W2000306855 cites W2026558983 @default.
• W2000306855 cites W2026886935 @default.
• W2000306855 cites W2030817463 @default.
• W2000306855 cites W2032352955 @default.
• W2000306855 cites W2033773654 @default.
• W2000306855 cites W2034643340 @default.
• W2000306855 cites W2036720692 @default.
• W2000306855 cites W2038419555 @default.
• W2000306855 cites W2039494893 @default.
• W2000306855 cites W2046076168 @default.
• W2000306855 cites W2055380784 @default.
• W2000306855 cites W2057824216 @default.
• W2000306855 cites W2059017998 @default.
• W2000306855 cites W2065546796 @default.
• W2000306855 cites W2066254885 @default.
• W2000306855 cites W2066729835 @default.
• W2000306855 cites W2067068509 @default.
• W2000306855 cites W2067150920 @default.
• W2000306855 cites W2068027420 @default.
• W2000306855 cites W2069885465 @default.
• W2000306855 cites W2070942720 @default.
• W2000306855 cites W2077720912 @default.
• W2000306855 cites W2081489881 @default.
• W2000306855 cites W2081838306 @default.
• W2000306855 cites W2086840459 @default.
• W2000306855 cites W2090148529 @default.
• W2000306855 cites W2104968232 @default.
• W2000306855 cites W2112041512 @default.
• W2000306855 cites W2124085296 @default.
• W2000306855 cites W2131697773 @default.
• W2000306855 cites W2133451731 @default.
• W2000306855 cites W2137241623 @default.
• W2000306855 cites W2142456895 @default.
• W2000306855 cites W2149472336 @default.
• W2000306855 cites W2160935383 @default.
• W2000306855 cites W2162218946 @default.
• W2000306855 cites W2166851454 @default.
• W2000306855 cites W2313729487 @default.
• W2000306855 cites W2409264701 @default.
• W2000306855 doi "https://doi.org/10.1002/jnr.21892" @default.
• W2000306855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18831059" @default.
• W2000306855 hasPublicationYear "2008" @default.
• W2000306855 type Work @default.
• W2000306855 sameAs 2000306855 @default.
• W2000306855 citedByCount "6" @default.
• W2000306855 countsByYear W20003068552014 @default.
• W2000306855 countsByYear W20003068552017 @default.
• W2000306855 countsByYear W20003068552019 @default.
• W2000306855 countsByYear W20003068552020 @default.
• W2000306855 crossrefType "journal-article" @default.
• W2000306855 hasAuthorship W2000306855A5011542402 @default.
• W2000306855 hasAuthorship W2000306855A5028704915 @default.
• W2000306855 hasAuthorship W2000306855A5029281471 @default.
• W2000306855 hasAuthorship W2000306855A5030113409 @default.
• W2000306855 hasAuthorship W2000306855A5030666031 @default.
• W2000306855 hasAuthorship W2000306855A5090445763 @default.
• W2000306855 hasConcept C142724271 @default.
• W2000306855 hasConcept C169760540 @default.
• W2000306855 hasConcept C181199279 @default.
• W2000306855 hasConcept C2776024655 @default.
• W2000306855 hasConcept C2777542381 @default.
• W2000306855 hasConcept C2777682930 @default.
• W2000306855 hasConcept C2779965356 @default.
• W2000306855 hasConcept C2781156865 @default.
• W2000306855 hasConcept C2908656565 @default.
• W2000306855 hasConcept C39398028 @default.
• W2000306855 hasConcept C529278444 @default.
• W2000306855 hasConcept C55493867 @default.

• next