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• W2000307227 abstract "We have recently shown both inhibitory and excitatory effects of serotonin on neonatal rat dorsal column axons. While neonatal rat dorsal column axons also respond to norepinephrine and GABA, adult rat dorsal columns are insensitive to the actions of both compounds. Therefore, we studied the effects of serotonin agonists on adult rat dorsal column axons using randomized double pulse stimuli at 0.2 Hz with random interpulse intervals of 3, 4, 5, 8, 10, 20, 30, 50 and 80 ms. The serotonin1A agonist, 8-hydroxy-dipropylaminotetralin-hydrobromide (8-OH-DPAT), significantly modulated test response amplitudes at 3, 4, 5 and 8 ms interpulse intervals by 29.6±4.0%, 17.4±2.1%, 9.6±2.3%, and 12.4±2.2% of conditioning pulse amplitudes, respectively. The mean latencies at 3, 4 and 5 ms interpulse intervals increased by 17.0±5.1%, 8.6±2.1%, and 5.1±1.4%, respectively (P<0.05). However, neither 10 μM 8-OH-DPAT nor 100 μM serotonin hydrochloride affected the compound action potentials evoked by conditioning or test pulses. In contrast, treatment with 100 μM quipazine dimaleate (a serotonin2A agonist) decreased the refractory period. While the response amplitudes to a 3-ms double pulse were reduced by 11.0±1.5% during the control period, the test response fell to only 2.4±1.8% of the conditioning response amplitudes after exposure to 100 μM quipazine. 8-OH-DPAT decreased the amplitude, prolonged the latency and increased the refractory periods of compound action potentials in the adult rat dorsal column, although a high concentration of the agonist (100 μM) was required for these effects. In contrast, the serotonin2A agonist, quipazine, decreased refractory periods. These results suggest that both serotonin1A and serotonin2A receptor subtypes are present on adult spinal dorsal column axons. Further, these receptors have opposing effects on axonal excitability, despite the fact that their sensitivities are relatively low." @default.
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• W2000307227 date "1997-07-01" @default.
• W2000307227 modified "2023-10-14" @default.
• W2000307227 title "Evidence for serotonin sensitivity of adult rat spinal axons: Studies using randomized double pulse stimulation" @default.
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• W2000307227 doi "https://doi.org/10.1016/s0306-4522(96)00708-7" @default.
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