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- W2000307893 abstract "Although the induction of nitric oxide (NO) synthesis has been implicated as a cause of cytokine-induced depression of cardiac β-adrenergic responsiveness. whether the NO system constitutively present in the normal myocardium plays a role in its physiologic response to β-adrenergic stimulation in vivo remains controversial. Accordingly, we examined the effects of low and high doses of N W -nitro-L-arginine methyl ester (L-NAME)(10 and 100 μg/kg/min for 10 min), an NO synthase inhibitor, administered into left circumflex coronary artery (LCX) on responses of peak left ventricular (LV) dP/dt, regional wall thickening in LCX region and LCX blood flow to graded intracoronary (IC) doses of isoproterenol (ISO:0.002 to 0.016 μg/kg/min) in 7 anesthetized dogs. IC L-NAME was associated with dose-related reductions in IC acetylcholine-induced coronary vasodilation. Effects of L-NAME on ISO-induced changes are shown: baseline ISO:0.002 0.004 0.008 .0016 Peak LV dP/dt (mmHg/sec) (n = 7) control 2029 ± 136 2586 ± 192 2820 ± 200 3309 ± 255 4120 ± 419 * low L-NAME 2171 ± 149 2566 ± 176 2894 ± 206 3214 ± 223 3707 ± 250 * high L-NAME 2114 ± 166 2326 ± 193 2560 ± 152 3014 ± 140 3354 ± 171 * Wall thickening (%) (n = 2) control 22 ± 7 25 ± 6 29 ± 5 33 ± 7 35 ± 9 low L-NAME 25 ± 11 25 ± 15 28 ± 19 31 ± 18 36 ± 21 high L-NAME 28 ± 17 25 ± 15 25 ± 15 31 ± 19 34 ± 15 LCX blood flow (ml/min)(n = 7) control 33 ± 6 48 ± 7 52 ± 6 61 ± 8 70 ± 9 * low L-NAME 36 ± 7 41 ± 8 44 ± 9 47 ± 8 52 ± 9 * high L-NAME 33 ± 7 36 ± 8 38 ± 7 40 ± 7 48 ± 8 * mean ± SEM * p < 0.05 Thus, inhibition of NO synthesis by L-NAME did not change baseline contractility nor did it increase its response to ISO. It also did not alter baseline blood flow, but reduced significantly its response to ISO. These data strongly suggest that the NO system in the normal myocardium does not modulate contractility, but NO formation in the vasculature contributes to the β-adrenergic coronary vasodilation." @default.
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- W2000307893 date "1995-02-01" @default.
- W2000307893 modified "2023-10-17" @default.
- W2000307893 title "744-3 Inhibition of Nitric Oxide Synthesis does not Increase Cardiac Contractile Response but Reduces Coronary Blood Flow Response to β-Adrenergic Stimulation in Normal Dogs" @default.
- W2000307893 doi "https://doi.org/10.1016/0735-1097(95)92232-t" @default.
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