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- W2000309805 abstract "Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion. In contrast, the role of the endosomal system is poorly understood in these parasites. With many typical endocytic factors missing, we speculated that endocytosis depends exclusively on a clathrin-mediated mechanism. Intriguingly, in Toxoplasma gondii we were only able to observe the endogenous clathrin heavy chain 1 (CHC1) at the Golgi, but not at the parasite surface. For the functional characterisation of Toxoplasma gondii CHC1 we generated parasite mutants conditionally expressing the dominant negative clathrin Hub fragment and demonstrate that CHC1 is essential for vesicle formation at the trans-Golgi network. Consequently, the functional ablation of CHC1 results in Golgi aberrations, a block in the biogenesis of the unique secretory microneme and rhoptry organelles, and of the pellicle. However, we found no morphological evidence for clathrin mediating endocytosis in these parasites and speculate that they remodelled their vesicular trafficking system to adapt to an intracellular lifestyle." @default.
- W2000309805 created "2016-06-24" @default.
- W2000309805 creator A5005237825 @default.
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- W2000309805 date "2013-10-11" @default.
- W2000309805 modified "2023-10-02" @default.
- W2000309805 title "The Role of Clathrin in Post-Golgi Trafficking in Toxoplasma gondii" @default.
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- W2000309805 doi "https://doi.org/10.1371/journal.pone.0077620" @default.
- W2000309805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795686" @default.
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