FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000310038> ?p ?o ?g. }

• W2000310038 endingPage "n/a" @default.
• W2000310038 startingPage "n/a" @default.
• W2000310038 abstract "Oxidative stress is a mediator of cell death following cerebral ischemia/reperfusion and heme toxicity, which can be an important pathogenic factor in acute brain injury. Induced expression of phase II detoxification enzymes through activation of the antioxidant response element (ARE)/Nrf2 pathway has emerged as a promising approach for neuroprotection. Little is known, however, about the neuroprotective potential of this strategy against injury in immature brain cells. In this study, we tested the hypothesis that sulforaphane (SFP), a naturally occurring isothiocyanate that is also a known activator of the ARE/Nrf2 antioxidant pathway, can protect immature neurons from oxidative stress-induced death. The hypothesis was tested with primary mouse hippocampal neurons exposed to either O(2) and glucose deprivation (OGD) or hemin. Treatment of immature neurons with SFP immediately after the OGD during reoxygenation was effective in protecting immature neurons from delayed cell death. Exposure of immature hippocampal neurons to hemin induced significant cell death, and both pre- and cotreatment with SFP were remarkably effective in blocking cytotoxicity. RT-PCR analysis indicated that several Nrf2-dependent cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO1), and glutamate-cysteine ligase modifier subunit (GCLM), which is involved in glutathione biosynthesis, were up-regulated following SFP treatment both in control neurons and following exposure to OGD and hemin. These results indicate that SFP activates the ARE/Nrf2 pathway of antioxidant defense and protects immature neurons from death caused by stress paradigms relevant to those associated with ischemic and traumatic injury to the immature brain." @default.
• W2000310038 created "2016-06-24" @default.
• W2000310038 creator A5019845840 @default.
• W2000310038 creator A5075383937 @default.
• W2000310038 creator A5080399968 @default.
• W2000310038 creator A5085295698 @default.
• W2000310038 date "2009-01-01" @default.
• W2000310038 modified "2023-10-12" @default.
• W2000310038 title "Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation" @default.
• W2000310038 cites W1417333514 @default.
• W2000310038 cites W1497523215 @default.
• W2000310038 cites W1826137220 @default.
• W2000310038 cites W1942154378 @default.
• W2000310038 cites W1972532680 @default.
• W2000310038 cites W1973081785 @default.
• W2000310038 cites W1984379577 @default.
• W2000310038 cites W1986099314 @default.
• W2000310038 cites W1986685890 @default.
• W2000310038 cites W1990661073 @default.
• W2000310038 cites W1990927292 @default.
• W2000310038 cites W1991530716 @default.
• W2000310038 cites W1999274929 @default.
• W2000310038 cites W2010740759 @default.
• W2000310038 cites W2015243552 @default.
• W2000310038 cites W2017319763 @default.
• W2000310038 cites W2020178430 @default.
• W2000310038 cites W2021270662 @default.
• W2000310038 cites W2021669660 @default.
• W2000310038 cites W2021946435 @default.
• W2000310038 cites W2022706428 @default.
• W2000310038 cites W2023062971 @default.
• W2000310038 cites W2030529426 @default.
• W2000310038 cites W2047499088 @default.
• W2000310038 cites W2065397424 @default.
• W2000310038 cites W2065690034 @default.
• W2000310038 cites W2066241876 @default.
• W2000310038 cites W2066729835 @default.
• W2000310038 cites W2070588153 @default.
• W2000310038 cites W2072438077 @default.
• W2000310038 cites W2076762501 @default.
• W2000310038 cites W2087311397 @default.
• W2000310038 cites W2089151769 @default.
• W2000310038 cites W2101283650 @default.
• W2000310038 cites W2101665923 @default.
• W2000310038 cites W2127165897 @default.
• W2000310038 cites W2129404156 @default.
• W2000310038 cites W2144303480 @default.
• W2000310038 cites W2166337262 @default.
• W2000310038 cites W2167978536 @default.
• W2000310038 doi "https://doi.org/10.1002/jnr.22307" @default.
• W2000310038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3037525" @default.
• W2000310038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19998483" @default.
• W2000310038 hasPublicationYear "2009" @default.
• W2000310038 type Work @default.
• W2000310038 sameAs 2000310038 @default.
• W2000310038 citedByCount "38" @default.
• W2000310038 countsByYear W20003100382012 @default.
• W2000310038 countsByYear W20003100382013 @default.
• W2000310038 countsByYear W20003100382015 @default.
• W2000310038 countsByYear W20003100382016 @default.
• W2000310038 countsByYear W20003100382017 @default.
• W2000310038 countsByYear W20003100382018 @default.
• W2000310038 countsByYear W20003100382019 @default.
• W2000310038 countsByYear W20003100382020 @default.
• W2000310038 countsByYear W20003100382021 @default.
• W2000310038 countsByYear W20003100382022 @default.
• W2000310038 countsByYear W20003100382023 @default.
• W2000310038 crossrefType "journal-article" @default.
• W2000310038 hasAuthorship W2000310038A5019845840 @default.
• W2000310038 hasAuthorship W2000310038A5075383937 @default.
• W2000310038 hasAuthorship W2000310038A5080399968 @default.
• W2000310038 hasAuthorship W2000310038A5085295698 @default.
• W2000310038 hasBestOaLocation W20003100382 @default.
• W2000310038 hasConcept C170493617 @default.
• W2000310038 hasConcept C178790620 @default.
• W2000310038 hasConcept C181199279 @default.
• W2000310038 hasConcept C185592680 @default.
• W2000310038 hasConcept C190283241 @default.
• W2000310038 hasConcept C25498285 @default.
• W2000310038 hasConcept C2776151105 @default.
• W2000310038 hasConcept C2776217839 @default.
• W2000310038 hasConcept C2777723881 @default.
• W2000310038 hasConcept C2779219270 @default.
• W2000310038 hasConcept C2779491297 @default.
• W2000310038 hasConcept C2779881523 @default.
• W2000310038 hasConcept C2781012912 @default.
• W2000310038 hasConcept C2781173740 @default.
• W2000310038 hasConcept C29730261 @default.
• W2000310038 hasConcept C31573885 @default.
• W2000310038 hasConcept C538909803 @default.
• W2000310038 hasConcept C55493867 @default.
• W2000310038 hasConcept C61174792 @default.
• W2000310038 hasConcept C86803240 @default.
• W2000310038 hasConcept C98274493 @default.
• W2000310038 hasConceptScore W2000310038C170493617 @default.
• W2000310038 hasConceptScore W2000310038C178790620 @default.
• W2000310038 hasConceptScore W2000310038C181199279 @default.
• W2000310038 hasConceptScore W2000310038C185592680 @default.

• next