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- W2000310424 abstract "1.The cells of the peri-insular acini have larger nuclei and zymogen regions and are refractory to the secretion stimulating action of pilocarpine, in contrast to the cells of the common acini (the halo phenomenon).2.In addition to the data in the literature suggesting a relation between the presence of insulin producing B-cells in the islets and the halo phenomenon, we have shown that the destruction of the B-cells by alloxan results in a disappearance of the haloes.3.The peri-insular cells incorporate more leucine-3H than the cells of the common acini. The larger mass of ergastoplasm mainly accounts for this increased protein synthesis, the incorporation per unit volume of ergastoplasm not being substantially increased.4.This great protein synthesis in cells maximally filled with zymogen granules is in accordance with our finding (Kramer and Poort, 1968) that the rate of protein synthesis in the cells of the rat pancreas is a constant one, independent of the phase of the secretory cycle. As in common acini, 90 per cent of the protein synthesized during 45 min, in the peri-insular acini of a “resting”, non stimulated gland is lost from the cells within 24 hours. As much protein must leave the cell as is synthesized in order to prevent overfilling.5.A short discussion is given on the influence insulin can have on the secretion and on the protein synthesis in the acinar cells." @default.
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- W2000310424 date "1968-01-01" @default.
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- W2000310424 title "The peri-insular acini of the pancreas of the rat" @default.
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- W2000310424 doi "https://doi.org/10.1007/bf00348522" @default.
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