Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000310814> ?p ?o ?g. }
- W2000310814 endingPage "296" @default.
- W2000310814 startingPage "290" @default.
- W2000310814 abstract "Age research in vertebrates is often limited by the longevity of available models. The teleost fish Nothobranchius furzeri has an exceptionally short lifespan with 3.5 months for the laboratory strain GRZ and about 6 months for the wild-derived strain MZM-0403. Here we have investigated telomere length in muscle and skin tissue of young and old fish of both strains using different methods. We found age-dependent telomere shortening in the MZM-0403 strain with the longer lifespan, whereas the short-lived GRZ strain showed no significant telomere shortening with advanced age. Sequencing of the two main telomerase genes Tert and Terc revealed that both genes are highly conserved between the N. furzeri strains while there is little conservation to other fish species and humans. Both genes are ubiquitously expressed in N. furzeri and expression levels of Tert and Terc correlate with telomerase activity in a tissue-specific manner. Unexpectedly, the expression level of Tert is increased in aged muscle and skin tissue of MZM-0403 suggesting that telomeres shorten upon ageing despite increased Tert expression and hence high telomerase activity. We further conclude that the extremely short lifespan of the GRZ strain is not caused by diminished telomerase activity or accelerated telomere shortening." @default.
- W2000310814 created "2016-06-24" @default.
- W2000310814 creator A5013067330 @default.
- W2000310814 creator A5028310893 @default.
- W2000310814 creator A5037620435 @default.
- W2000310814 creator A5038739278 @default.
- W2000310814 creator A5042480855 @default.
- W2000310814 creator A5042704646 @default.
- W2000310814 creator A5042912205 @default.
- W2000310814 creator A5047756154 @default.
- W2000310814 creator A5053296448 @default.
- W2000310814 creator A5069939055 @default.
- W2000310814 creator A5076709854 @default.
- W2000310814 creator A5086342180 @default.
- W2000310814 date "2009-05-01" @default.
- W2000310814 modified "2023-09-23" @default.
- W2000310814 title "Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri" @default.
- W2000310814 cites W1519233253 @default.
- W2000310814 cites W1872697492 @default.
- W2000310814 cites W1965254421 @default.
- W2000310814 cites W1974317814 @default.
- W2000310814 cites W1975488499 @default.
- W2000310814 cites W1976273464 @default.
- W2000310814 cites W1983673827 @default.
- W2000310814 cites W1986808310 @default.
- W2000310814 cites W1988910648 @default.
- W2000310814 cites W1989289507 @default.
- W2000310814 cites W1995925983 @default.
- W2000310814 cites W1996423252 @default.
- W2000310814 cites W2000971601 @default.
- W2000310814 cites W2004740296 @default.
- W2000310814 cites W2020038227 @default.
- W2000310814 cites W2023237712 @default.
- W2000310814 cites W2025843494 @default.
- W2000310814 cites W2026856852 @default.
- W2000310814 cites W2027581280 @default.
- W2000310814 cites W2028027727 @default.
- W2000310814 cites W2034090560 @default.
- W2000310814 cites W2035375803 @default.
- W2000310814 cites W2036395225 @default.
- W2000310814 cites W2037236933 @default.
- W2000310814 cites W2042377388 @default.
- W2000310814 cites W2043204829 @default.
- W2000310814 cites W2045702252 @default.
- W2000310814 cites W2054684152 @default.
- W2000310814 cites W2061440932 @default.
- W2000310814 cites W2062168762 @default.
- W2000310814 cites W2063993421 @default.
- W2000310814 cites W2073506065 @default.
- W2000310814 cites W2079378073 @default.
- W2000310814 cites W2081193579 @default.
- W2000310814 cites W2084786788 @default.
- W2000310814 cites W2099249565 @default.
- W2000310814 cites W2099686357 @default.
- W2000310814 cites W2100702324 @default.
- W2000310814 cites W2101512588 @default.
- W2000310814 cites W2108482850 @default.
- W2000310814 cites W2111092938 @default.
- W2000310814 cites W2114375142 @default.
- W2000310814 cites W2115176808 @default.
- W2000310814 cites W2117824620 @default.
- W2000310814 cites W2120086108 @default.
- W2000310814 cites W2145859123 @default.
- W2000310814 cites W2160185049 @default.
- W2000310814 cites W2160621707 @default.
- W2000310814 cites W2169581310 @default.
- W2000310814 doi "https://doi.org/10.1016/j.mad.2009.01.003" @default.
- W2000310814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19428446" @default.
- W2000310814 hasPublicationYear "2009" @default.
- W2000310814 type Work @default.
- W2000310814 sameAs 2000310814 @default.
- W2000310814 citedByCount "107" @default.
- W2000310814 countsByYear W20003108142012 @default.
- W2000310814 countsByYear W20003108142013 @default.
- W2000310814 countsByYear W20003108142014 @default.
- W2000310814 countsByYear W20003108142015 @default.
- W2000310814 countsByYear W20003108142016 @default.
- W2000310814 countsByYear W20003108142017 @default.
- W2000310814 countsByYear W20003108142018 @default.
- W2000310814 countsByYear W20003108142019 @default.
- W2000310814 countsByYear W20003108142020 @default.
- W2000310814 countsByYear W20003108142021 @default.
- W2000310814 countsByYear W20003108142022 @default.
- W2000310814 countsByYear W20003108142023 @default.
- W2000310814 crossrefType "journal-article" @default.
- W2000310814 hasAuthorship W2000310814A5013067330 @default.
- W2000310814 hasAuthorship W2000310814A5028310893 @default.
- W2000310814 hasAuthorship W2000310814A5037620435 @default.
- W2000310814 hasAuthorship W2000310814A5038739278 @default.
- W2000310814 hasAuthorship W2000310814A5042480855 @default.
- W2000310814 hasAuthorship W2000310814A5042704646 @default.
- W2000310814 hasAuthorship W2000310814A5042912205 @default.
- W2000310814 hasAuthorship W2000310814A5047756154 @default.
- W2000310814 hasAuthorship W2000310814A5053296448 @default.
- W2000310814 hasAuthorship W2000310814A5069939055 @default.
- W2000310814 hasAuthorship W2000310814A5076709854 @default.
- W2000310814 hasAuthorship W2000310814A5086342180 @default.
- W2000310814 hasBestOaLocation W20003108141 @default.