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• W2000311549 abstract "The three members of the Brn-3 subfamily of POU transcription factors have distinct effects on target gene expression. We show that the promoter of the gene encoding the presynaptic nerve terminal protein SNAP-25 resembles previously characterised target genes in being activated by Brn-3a and Brn-3c, but being repressed by Brn-3b. Unlike other target genes, however, the SNAP-25 promoter can be activated by either the N- or C-terminal activation domains of Brn-3a. In contrast to the SNAP-25 gene, the gene encoding the synaptic vesicle protein synapsin I is activated by all the Brn-3 factors, the first gene for which this activation pattern has been reported. Interestingly, however, similar activation by all three Brn-3 factors can be observed if the SNAP-25 promoter is truncated by removal of sequences from −2200 to −288 relative to the transcriptional start site. Moreover, a region of the SNAP-25 promoter from −288 to −126 can render a heterologous promoter responsive to activation by all three Brn-3 factors. Differences in promoter structure may thus result in differences in the response to different Brn-3 factors, thus allowing these factors to produce diverse activation patterns of neuronally expressed genes, such as those encoding different synaptic proteins." @default.
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• W2000311549 date "1996-12-01" @default.
• W2000311549 modified "2023-09-27" @default.
• W2000311549 title "Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors" @default.
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• W2000311549 doi "https://doi.org/10.1016/s0169-328x(96)00207-0" @default.
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