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- W2000312001 abstract "Diapedesis is a vital part of tumour metastasis, whereby tumour cells attach to and cross the endothelium to enter the circulation. Specific adhesion molecules, expressed by both the tumour and endothelial cells, mediate this process. This review summarises recent findings regarding the mechanisms by which colon cancer cells migrate through the endothelium under flow conditions mediated by E-selectin. Using a laminar flow chamber and a tissue engineered human blood vessel, E-selectin was found to regulate initial attachment and rolling of colon cancer cells and also the subsequent diapedesis through the endothelium. Three different mechanisms of diapedesis were reported to be regulated by E-selectin; the formation of a mosaic chimeric layer of tissue, paracellular diapedesis between endothelial cells and transcellular diapedesis, in which tumour cells were transported via large vacuoles within the endothelial cells. Moreover activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase by E-selectin was further required for paracellular diapedesis. This study is the first to report these observations under dynamic and shear stress conditions." @default.
- W2000312001 created "2016-06-24" @default.
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- W2000312001 date "2008-07-01" @default.
- W2000312001 modified "2023-09-27" @default.
- W2000312001 title "Crossing the endothelium" @default.
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- W2000312001 doi "https://doi.org/10.4161/cam.2.3.6820" @default.
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