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• W2000313746 abstract "ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic receptors. A mechanism involving an interaction of ACTH-(1-24) with the phospholipid core of the receptors is suggested. Structure activity studies point to a relation with reported effects of intracerebroventricularly administered ACTH on the turnover rate of acetylcholine and the ACTH-induced stretching and yawning syndrome." @default.
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• W2000313746 date "1986-05-01" @default.
• W2000313746 modified "2023-09-27" @default.
• W2000313746 title "In vitro interaction of ACTH with rat brain muscarinic receptors" @default.
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• W2000313746 doi "https://doi.org/10.1016/0196-9781(86)90009-4" @default.
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