FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000313859> ?p ?o ?g. }

• W2000313859 endingPage "354" @default.
• W2000313859 startingPage "348" @default.
• W2000313859 abstract "Benign thyroid nodules are common in iodine deficient countries. Although many recent studies have addressed the molecular basis and short-term outcome of treatment in nodular thyroid disease, data on the long-term follow-up of thyroid nodule growth are widely lacking. The aim of the present study was to evaluate the long-term behaviour of benign thyroid nodules growth. We followed 109 consecutive patients seen at yearly intervals in our Outpatient Clinic for at least 3 years (range 3-12 years, mean 4.9 +/- 2.6 years) presenting with 139 benign nodules in uni- or multinodular goiters. The size of the nodules and thyroid glands was analysed retrospectively. The study included a spectrum of benign thyroid nodules, 86 functioning and 53 non-functioning. 27 patients were treated with levothyroxine, 8 with iodide and 16 with a combination of both. 58 patients were not treated mainly because of thyroid functional autonomy. Patients with overt hyperthyroidism or suspected malignancy by fine-needle aspiration were excluded from the study. The nodules and glands were assessed by ultrasonography at yearly intervals and documented by photoprints. Relevant growth was defined as an increase in nodule volume of at least 30%. For statistical analyses, Cox Proportional Hazard Model and life-table analyses according to Kaplan-Meier were performed. Most thyroid nodules grew slowly but continuously during follow-up. After about 3 years, half of the nodules had increased their volume by at least 30%. Growth of the nodules was significantly faster than of the corresponding thyroid glands (p < 0.0001). Age and sex of the patients and size or function of the nodules at initial presentation were not significantly related to their growth. Suppression of TSH did not affect growth of the nodules irrespective of the source of thyroid hormones, endogenous or by administration of levothyroxine. In conclusion, benign thyroid nodules have a slow intrinsic growth potential, which is apparently higher than that of the non-nodular tissue. In this study, not only nodular but even non-nodular goiter growth continues in the majority of patients. Exogeneous factors, including therapy with levothyroxine and/or iodide, appear to have little effect on the growth behaviour." @default.
• W2000313859 created "2016-06-24" @default.
• W2000313859 creator A5005371650 @default.
• W2000313859 creator A5008355737 @default.
• W2000313859 creator A5020403541 @default.
• W2000313859 creator A5029264958 @default.
• W2000313859 creator A5034614695 @default.
• W2000313859 creator A5038428752 @default.
• W2000313859 creator A5074292475 @default.
• W2000313859 date "2002-10-24" @default.
• W2000313859 modified "2023-09-25" @default.
• W2000313859 title "Long-Term Follow-up of Thyroid Nodule Growth" @default.
• W2000313859 doi "https://doi.org/10.1055/s-2002-34992" @default.
• W2000313859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12397534" @default.
• W2000313859 hasPublicationYear "2002" @default.
• W2000313859 type Work @default.
• W2000313859 sameAs 2000313859 @default.
• W2000313859 citedByCount "67" @default.
• W2000313859 countsByYear W20003138592013 @default.
• W2000313859 countsByYear W20003138592014 @default.
• W2000313859 countsByYear W20003138592015 @default.
• W2000313859 countsByYear W20003138592016 @default.
• W2000313859 countsByYear W20003138592018 @default.
• W2000313859 countsByYear W20003138592019 @default.
• W2000313859 countsByYear W20003138592020 @default.
• W2000313859 countsByYear W20003138592021 @default.
• W2000313859 crossrefType "journal-article" @default.
• W2000313859 hasAuthorship W2000313859A5005371650 @default.
• W2000313859 hasAuthorship W2000313859A5008355737 @default.
• W2000313859 hasAuthorship W2000313859A5020403541 @default.
• W2000313859 hasAuthorship W2000313859A5029264958 @default.
• W2000313859 hasAuthorship W2000313859A5034614695 @default.
• W2000313859 hasAuthorship W2000313859A5038428752 @default.
• W2000313859 hasAuthorship W2000313859A5074292475 @default.
• W2000313859 hasConcept C126322002 @default.
• W2000313859 hasConcept C126838900 @default.
• W2000313859 hasConcept C151730666 @default.
• W2000313859 hasConcept C207103383 @default.
• W2000313859 hasConcept C2775883008 @default.
• W2000313859 hasConcept C2776731575 @default.
• W2000313859 hasConcept C2779022025 @default.
• W2000313859 hasConcept C2779399171 @default.
• W2000313859 hasConcept C44249647 @default.
• W2000313859 hasConcept C526584372 @default.
• W2000313859 hasConcept C71924100 @default.
• W2000313859 hasConcept C86803240 @default.
• W2000313859 hasConceptScore W2000313859C126322002 @default.
• W2000313859 hasConceptScore W2000313859C126838900 @default.
• W2000313859 hasConceptScore W2000313859C151730666 @default.
• W2000313859 hasConceptScore W2000313859C207103383 @default.
• W2000313859 hasConceptScore W2000313859C2775883008 @default.
• W2000313859 hasConceptScore W2000313859C2776731575 @default.
• W2000313859 hasConceptScore W2000313859C2779022025 @default.
• W2000313859 hasConceptScore W2000313859C2779399171 @default.
• W2000313859 hasConceptScore W2000313859C44249647 @default.
• W2000313859 hasConceptScore W2000313859C526584372 @default.
• W2000313859 hasConceptScore W2000313859C71924100 @default.
• W2000313859 hasConceptScore W2000313859C86803240 @default.
• W2000313859 hasIssue "07" @default.
• W2000313859 hasLocation W20003138591 @default.
• W2000313859 hasLocation W20003138592 @default.
• W2000313859 hasOpenAccess W2000313859 @default.
• W2000313859 hasPrimaryLocation W20003138591 @default.
• W2000313859 hasRelatedWork W1993750017 @default.
• W2000313859 hasRelatedWork W2028726180 @default.
• W2000313859 hasRelatedWork W2052691691 @default.
• W2000313859 hasRelatedWork W2157743352 @default.
• W2000313859 hasRelatedWork W2320028910 @default.
• W2000313859 hasRelatedWork W2402012517 @default.
• W2000313859 hasRelatedWork W3129675663 @default.
• W2000313859 hasRelatedWork W3159402250 @default.
• W2000313859 hasRelatedWork W3196298838 @default.
• W2000313859 hasRelatedWork W3202703666 @default.
• W2000313859 hasVolume "110" @default.
• W2000313859 isParatext "false" @default.
• W2000313859 isRetracted "false" @default.
• W2000313859 magId "2000313859" @default.
• W2000313859 workType "article" @default.