FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000313884> ?p ?o ?g. }

• W2000313884 endingPage "455" @default.
• W2000313884 startingPage "447" @default.
• W2000313884 abstract "The ability to productively infect monocytes/macrophages is the most important difference between the low virulent feline enteric coronavirus (FECV) and the lethal feline infectious peritonitis virus (FIPV). In vitro, the replication of FECV in peripheral blood monocytes always drops after 12 h post inoculation, while FIPV sustains its replication in the monocytes from 45% of the cats. The accessory proteins of feline coronaviruses have been speculated to play a prominent role in virulence as deletions were found to be associated with attenuated viruses. Still, no functions have been ascribed to them. In order to investigate if the accessory proteins of FIPV are important for sustaining its replication in monocytes, replication kinetics were determined for FIPV 79-1146 and its deletion mutants, lacking either accessory protein open reading frame 3abc (FIPV-Δ3), 7ab (FIPV-Δ7) or both (FIPV-Δ3Δ7). Results showed that the deletion mutants FIPV-Δ7 and FIPV-Δ3Δ7 could not maintain their replication, which was in sharp contrast to wt-FIPV. FIPV-Δ3 could still sustain its replication, but the percentage of infected monocytes was always lower compared to wt-FIPV. In conclusion, this study showed that ORF7 is crucial for FIPV replication in monocytes/macrophages, giving an explanation for its importance in vivo, its role in the development of FIP and its conservation in field strains. The effect of an ORF3 deletion was less pronounced, indicating only a supportive role of ORF3 encoded proteins during the infection of the in vivo target cell by FIPVs." @default.
• W2000313884 created "2016-06-24" @default.
• W2000313884 creator A5024074063 @default.
• W2000313884 creator A5033950612 @default.
• W2000313884 creator A5057339089 @default.
• W2000313884 creator A5062878756 @default.
• W2000313884 creator A5066177675 @default.
• W2000313884 creator A5070434015 @default.
• W2000313884 date "2013-03-01" @default.
• W2000313884 modified "2023-09-26" @default.
• W2000313884 title "The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes" @default.
• W2000313884 cites W1969841753 @default.
• W2000313884 cites W1972419862 @default.
• W2000313884 cites W1988862183 @default.
• W2000313884 cites W1989458256 @default.
• W2000313884 cites W1990176346 @default.
• W2000313884 cites W2001871525 @default.
• W2000313884 cites W2011667588 @default.
• W2000313884 cites W2023225208 @default.
• W2000313884 cites W2028401536 @default.
• W2000313884 cites W2031319142 @default.
• W2000313884 cites W2039979773 @default.
• W2000313884 cites W2040713626 @default.
• W2000313884 cites W2061960955 @default.
• W2000313884 cites W2098939618 @default.
• W2000313884 cites W2099450221 @default.
• W2000313884 cites W2101661393 @default.
• W2000313884 cites W2102206522 @default.
• W2000313884 cites W2104481743 @default.
• W2000313884 cites W2107258315 @default.
• W2000313884 cites W2115954164 @default.
• W2000313884 cites W2123702495 @default.
• W2000313884 cites W2126959222 @default.
• W2000313884 cites W2130270208 @default.
• W2000313884 cites W2132382998 @default.
• W2000313884 cites W2135479945 @default.
• W2000313884 cites W2139405922 @default.
• W2000313884 cites W2139682436 @default.
• W2000313884 cites W2156151768 @default.
• W2000313884 cites W2165899210 @default.
• W2000313884 cites W2166135499 @default.
• W2000313884 cites W2256756668 @default.
• W2000313884 cites W4253136389 @default.
• W2000313884 doi "https://doi.org/10.1016/j.vetmic.2012.10.032" @default.
• W2000313884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7117191" @default.
• W2000313884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23182908" @default.
• W2000313884 hasPublicationYear "2013" @default.
• W2000313884 type Work @default.
• W2000313884 sameAs 2000313884 @default.
• W2000313884 citedByCount "24" @default.
• W2000313884 countsByYear W20003138842013 @default.
• W2000313884 countsByYear W20003138842014 @default.
• W2000313884 countsByYear W20003138842016 @default.
• W2000313884 countsByYear W20003138842018 @default.
• W2000313884 countsByYear W20003138842019 @default.
• W2000313884 countsByYear W20003138842020 @default.
• W2000313884 countsByYear W20003138842021 @default.
• W2000313884 countsByYear W20003138842022 @default.
• W2000313884 countsByYear W20003138842023 @default.
• W2000313884 crossrefType "journal-article" @default.
• W2000313884 hasAuthorship W2000313884A5024074063 @default.
• W2000313884 hasAuthorship W2000313884A5033950612 @default.
• W2000313884 hasAuthorship W2000313884A5057339089 @default.
• W2000313884 hasAuthorship W2000313884A5062878756 @default.
• W2000313884 hasAuthorship W2000313884A5066177675 @default.
• W2000313884 hasAuthorship W2000313884A5070434015 @default.
• W2000313884 hasBestOaLocation W20003138841 @default.
• W2000313884 hasConcept C104317684 @default.
• W2000313884 hasConcept C140704245 @default.
• W2000313884 hasConcept C142724271 @default.
• W2000313884 hasConcept C159047783 @default.
• W2000313884 hasConcept C2522874641 @default.
• W2000313884 hasConcept C2776844884 @default.
• W2000313884 hasConcept C2777648638 @default.
• W2000313884 hasConcept C2779134260 @default.
• W2000313884 hasConcept C2779937474 @default.
• W2000313884 hasConcept C3008058167 @default.
• W2000313884 hasConcept C524204448 @default.
• W2000313884 hasConcept C54355233 @default.
• W2000313884 hasConcept C60987743 @default.
• W2000313884 hasConcept C71924100 @default.
• W2000313884 hasConcept C86803240 @default.
• W2000313884 hasConceptScore W2000313884C104317684 @default.
• W2000313884 hasConceptScore W2000313884C140704245 @default.
• W2000313884 hasConceptScore W2000313884C142724271 @default.
• W2000313884 hasConceptScore W2000313884C159047783 @default.
• W2000313884 hasConceptScore W2000313884C2522874641 @default.
• W2000313884 hasConceptScore W2000313884C2776844884 @default.
• W2000313884 hasConceptScore W2000313884C2777648638 @default.
• W2000313884 hasConceptScore W2000313884C2779134260 @default.
• W2000313884 hasConceptScore W2000313884C2779937474 @default.
• W2000313884 hasConceptScore W2000313884C3008058167 @default.
• W2000313884 hasConceptScore W2000313884C524204448 @default.
• W2000313884 hasConceptScore W2000313884C54355233 @default.
• W2000313884 hasConceptScore W2000313884C60987743 @default.
• W2000313884 hasConceptScore W2000313884C71924100 @default.
• W2000313884 hasConceptScore W2000313884C86803240 @default.
• W2000313884 hasIssue "2-4" @default.

• next