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- W2000314222 abstract "The orexin (Orx)/hypocretin system has been implicated in reward-seeking, especially for highly salient food and drug rewards. We recently demonstrated that signaling at the OxR1 receptor is involved in sucrose reinforcement and reinstatement of sucrose-seeking elicited by sucrose-paired cues in food-restricted rats. Because sucrose reinforcement has both a hedonic and caloric component, it remains unknown what aspect of this reward drives its reinforcing value.The present study examined the involvement of the Orx system in operant responding for saccharin, a noncaloric, hedonic (sweet) reward, and in cue-induced reinstatement of extinguished saccharin-seeking in ad libitum-fed vs food-restricted male subjects.Male Sprague Dawley rats were fed ad libitum or food-restricted and trained to self-administer saccharin. We determined the effects of pretreatment with the OxR1 receptor antagonist SB-334867 (SB; 10-30 mg/kg) on fixed ratio (FR) saccharin self-administration and on cue-induced reinstatement of extinguished saccharin-seeking.SB decreased responding and number of reinforcers earned during FR responding for saccharin and decreased cue-induced reinstatement of extinguished saccharin-seeking. All of these effects were obtained similarly in food-restricted and ad libitum-fed rats.These results indicate that signaling at the OxR1 receptor is involved in saccharin reinforcement and reinstatement of saccharin-seeking elicited by saccharin-paired cues regardless of food restriction. These findings lead us to conclude that the Orx system contributes to the motivational effects of hedonic food rewards, independently of caloric value and homeostatic needs." @default.
- W2000314222 created "2016-06-24" @default.
- W2000314222 creator A5030113568 @default.
- W2000314222 creator A5082673998 @default.
- W2000314222 date "2013-03-15" @default.
- W2000314222 modified "2023-09-27" @default.
- W2000314222 title "Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist" @default.
- W2000314222 cites W1482425500 @default.
- W2000314222 cites W1488496267 @default.
- W2000314222 cites W1503226828 @default.
- W2000314222 cites W1511397211 @default.
- W2000314222 cites W1566047568 @default.
- W2000314222 cites W1627229807 @default.
- W2000314222 cites W1942204598 @default.
- W2000314222 cites W1945866681 @default.
- W2000314222 cites W1965134469 @default.
- W2000314222 cites W1966330898 @default.
- W2000314222 cites W1966793802 @default.
- W2000314222 cites W1968914473 @default.
- W2000314222 cites W1976051280 @default.
- W2000314222 cites W1976544983 @default.
- W2000314222 cites W1985055240 @default.
- W2000314222 cites W1985687179 @default.
- W2000314222 cites W1988214208 @default.
- W2000314222 cites W1990388529 @default.
- W2000314222 cites W1997573433 @default.
- W2000314222 cites W1997993650 @default.
- W2000314222 cites W2001446466 @default.
- W2000314222 cites W2002532911 @default.
- W2000314222 cites W2005241850 @default.
- W2000314222 cites W2005409308 @default.
- W2000314222 cites W2005434304 @default.
- W2000314222 cites W2007511567 @default.
- W2000314222 cites W2023425789 @default.
- W2000314222 cites W2026807927 @default.
- W2000314222 cites W2027914871 @default.
- W2000314222 cites W2029119693 @default.
- W2000314222 cites W2031357481 @default.
- W2000314222 cites W2038944901 @default.
- W2000314222 cites W2041275777 @default.
- W2000314222 cites W2041549838 @default.
- W2000314222 cites W2042388304 @default.
- W2000314222 cites W2046337543 @default.
- W2000314222 cites W2052761645 @default.
- W2000314222 cites W2053292430 @default.
- W2000314222 cites W2053359936 @default.
- W2000314222 cites W2056106142 @default.
- W2000314222 cites W2058094768 @default.
- W2000314222 cites W2058288237 @default.
- W2000314222 cites W2062084429 @default.
- W2000314222 cites W2069149345 @default.
- W2000314222 cites W2070413695 @default.
- W2000314222 cites W2071531229 @default.
- W2000314222 cites W2074617349 @default.
- W2000314222 cites W2075110848 @default.
- W2000314222 cites W2076837762 @default.
- W2000314222 cites W2081140331 @default.
- W2000314222 cites W2084682408 @default.
- W2000314222 cites W2087173041 @default.
- W2000314222 cites W2091496200 @default.
- W2000314222 cites W2093110870 @default.
- W2000314222 cites W2093684418 @default.
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- W2000314222 cites W2117879547 @default.
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- W2000314222 cites W2124281635 @default.
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- W2000314222 cites W2161088709 @default.
- W2000314222 cites W2164595661 @default.
- W2000314222 cites W2171515425 @default.
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- W2000314222 doi "https://doi.org/10.1007/s00213-013-3051-7" @default.
- W2000314222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3707982" @default.
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