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• W2000314225 abstract "Valorar la respuesta y la supervivencia utilizando tratamiento hormonoterápico en pacientes con cáncer de mama no subsidiarias de cirugía. Estudio retrospectivo de 153 pacientes con carcinoma de mama no operable por enfermedad extensa, edad avanzada, comorbilidad grave o rechazo a la terapia convencional, tratadas con hormonoterapia. Valoramos el estadio inicial, la respuesta, la supervivencia global y hasta el primer evento así como causas de fallecimiento. La edad media ± desviación estándar fue 79 ± 7 años y el seguimiento medio 42,6 meses (0-180 meses). Al diagnóstico, 22% presentaba T4; el 47%, afectación ganglionar clínica, y el 16%, enfermedad metastásica. El 87,7% recibió tamoxifeno y el resto, inhibidores de aromatasa o megestrol. El 22% tuvo otros tratamientos sucesivos. El 5,8% presentó respuesta completa; el 31,8%, parcial; el 34,4%, estabilización, y el 9,7%, progresión. El primer evento apareció a 35,7 ± 33 meses de seguimiento. La mortalidad global a 5 años fue del 68,6% y la mortalidad debida a cáncer de mama del 57,3%. La hormonoterapia puede plantearse como primera opción en estas pacientes al ser eficaz con escasos efectos secundarios. To analyze the response to hormonotherapy and survival in non-surgical breast cancer patients. We performed a retrospective study of 153 patients with inoperable breast carcinoma due to advanced disease, advanced age, severe comorbidity or refusal to accept conventional therapy, who were treated with hormonotherapy. Initial tumoral stage, response, overall survival and causes of death were evaluated. The mean age was 79 ± 7 years with a mean follow-up of 42.6 months (range: 0-180). At diagnosis, stage T4 tumors were found in 22%, clinical nodal involvement was found in 47% and metastasis in 16%. Tamoxifen was administered in 87.7% of the patients and aromatase inhibitors or megestrol in the remainder. Successive treatments were required in 22%. Complete response occurred in 5.8% and partial response in 31.8%. Of the remaining patients, 34.4% remained stable and 9.7% showed disease progression. The first event occurred at 35.7 ± 33 months of follow-up. Overall mortality was 68.7% and breast cancer mortality was 57.3%. Because of its efficacy and scarce adverse effects, hormonotherapy may be an effective treatment in non-surgical patients with breast carcinoma." @default.
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• W2000314225 date "2009-01-01" @default.
• W2000314225 modified "2023-10-17" @default.
• W2000314225 title "Hormonoterapia como primer tratamiento en pacientes no subsidiarias de cirugía en cáncer de mama" @default.
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• W2000314225 doi "https://doi.org/10.1016/s0304-5013(09)70140-2" @default.
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